(Q27342729)

26 June 2017

title

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing (English)

1 reference

26 June 2017

23

Kim Zarse

Kim

Zarse

1 reference

26 June 2017

24

Michael Ristow

Michael

Ristow

1 reference

26 June 2017

Christoph Kaleta

19

Christoph

Kaleta

1 reference

PubMed

19 October 2023

Christoph Englert

17

Christoph

Englert

1 reference

PubMed

19 October 2023

20

Matthias Platzer

Matthias

Platzer

1 reference

26 June 2017

10

Sebastian Schmeisser

Sebastian

Schmeisser

1 reference

26 June 2017

11

Doreen Kuhlow

Doreen

Kuhlow

1 reference

26 June 2017

14

Peter Hemmerich

Peter

Hemmerich

1 reference

26 June 2017

18

Reinhard Guthke

Reinhard

Guthke

1 reference

26 June 2017

15

Michael Kiehntopf

Michael

Kiehntopf

1 reference

26 June 2017

3

Steffen Priebe

Steffen

Priebe

1 reference

26 June 2017

4

Marco Groth

Marco

Groth

1 reference

26 June 2017

16

Nicola Zamboni

Nicola

Zamboni

2 references

26 June 2017

ORCID Public Data File 2021

Johannes Mansfeld

1

Johannes

Mansfeld

1 reference

26 June 2017

Nadine Urban

2

Nadine

Urban

1 reference

26 June 2017

Christiane Frahm

5

Christiane

Frahm

1 reference

26 June 2017

Nils Hartmann

6

Nils

Hartmann

1 reference

26 June 2017

Juliane Gebauer

7

Juliane

Gebauer

1 reference

26 June 2017

Meenakshi Ravichandran

8

Meenakshi

Ravichandran

1 reference

26 June 2017

Anne Dommaschk

9

Anne

Dommaschk

1 reference

26 June 2017

Shamci Monajembashi

12

Shamci

Monajembashi

1 reference

26 June 2017

Sibylle Bremer-Streck

13

Sibylle

Bremer-Streck

1 reference

26 June 2017

Jürgen Sühnel

21

Jürgen

Sühnel

1 reference

26 June 2017

Otto W Witte

22

Otto W

Witte

1 reference

26 June 2017

language of work or name

English

0 references

publication date

1 December 2015

1 reference

26 June 2017

published in

Nature Communications

1 reference

26 June 2017

volume

6

1 reference

26 June 2017

page(s)

10043

1 reference

Creative Commons Attribution 4.0 International

26 June 2017

copyright license

start time

1 December 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

TGF-β signaling in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

mTOR is a key modulator of ageing and age-related disease

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Differential expression analysis for sequence count data

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

GAGE: generally applicable gene set enrichment for pathway analysis

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Mapping and quantifying mammalian transcriptomes by RNA-Seq

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

The Parallel Worm Tracker: a platform for measuring average speed and drug-induced paralysis in nematodes

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

The genetics of Caenorhabditis elegans

21 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

21 March 2017

27 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1038/NCOMMS10043

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

A C. elegans mutant that lives twice as long as wild type

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Measurement of protein using bicinchoninic acid

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Hypothalamic mTOR signaling regulates food intake

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Dynamic network reconstruction from gene expression data applied to immune response during bacterial infection

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Branched chain aminotransferase isoenzymes. Purification and characterization of the rat brain isoenzyme

21 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

21 March 2017

27 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1038/NCOMMS10043

TRANSFAC: transcriptional regulation, from patterns to profiles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Physiological roles of mitochondrial reactive oxygen species

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Two neurons mediate diet-restriction-induced longevity in C. elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

JASPAR: an open-access database for eukaryotic transcription factor binding profiles

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Extended longevity in mice lacking the insulin receptor in adipose tissue

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Nonalcoholic fatty liver disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Mitochondrial ROS signaling in organismal homeostasis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

AMPK at the nexus of energetics and aging.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Hypothalamic mTOR: the rookie energy sensor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

WormBase 2014: new views of curated biology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Heat shock factor-1 intertwines insulin/IGF-1, TGF-β and cGMP signaling to control development and aging

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

On the programmed/non-programmed nature of ageing within the life history

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Efficient Implementation of the Fuzzy c-Means Clustering Algorithms.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

baySeq: empirical Bayesian methods for identifying differential expression in sequence count data

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Enhanced neuronal RNAi in C. elegans using SID-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

A metabolic signature of long life in Caenorhabditis elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Using RSAT to scan genome sequences for transcription factor binding sites and cis-regulatory modules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Gene expression in human NAFLD.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

A systematic RNAi screen for longevity genes in C. elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Comparing genomic expression patterns across species identifies shared transcriptional profile in aging

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Dwarf mice and the ageing process.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

What is an anti-aging treatment?

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

The Longevity of Sirtuins

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Reduced insulin/IGF-1 signalling and human longevity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686672

Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26620638

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1 reference

27 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1038/NCOMMS10043

Identifiers

DOI

10.1038/NCOMMS10043

1 reference

Dimensions Publication ID

26 June 2017

0 references

1035283237

0 references

PMC publication ID

4686672

0 references

1 reference