(Q27488430)

English

Mutations in Hepatitis C Virus E2 Located outside the CD81 Binding Sites Lead to Escape from Broadly Neutralizing Antibodies but Compromise Virus Infectivity

scientific article (publication date: June 2009)

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scholarly article

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Mutations in Hepatitis C Virus E2 Located outside the CD81 Binding Sites Lead to Escape from Broadly Neutralizing Antibodies but Compromise Virus Infectivity (English)

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based on heuristic

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Hepatitis C virus

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based on heuristic

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based on heuristic

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based on heuristic

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object named as

Peter Balfe

5

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Jane A. McKeating

object named as

Jane A McKeating

6

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Harvey J. Alter

9

object named as

Harvey Alter

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Charles M. Rice

10

object named as

Charles M Rice

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11

object named as

Steven K H Foung

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1

object named as

Zhen-yong Keck

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8

object named as

Arvind H Patel

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3

object named as

Jinming Xia

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author name string

Sophia H Li

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Thomas von Hahn

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Jeroen Witteveldt

7

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publication date

June 2009

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Journal of Virology

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83

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12

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6149-60

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In vitro selection of a neutralization-resistant hepatitis C virus escape mutant

1 reference

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20 March 2017

Definition of a Conserved Immunodominant Domain on Hepatitis C Virus E2 Glycoprotein by Neutralizing Human Monoclonal Antibodies

1 reference

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20 March 2017

A Point Mutation Leading to Hepatitis C Virus Escape from Neutralization by a Monoclonal Antibody to a Conserved Conformational Epitope

1 reference

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20 March 2017

Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: Putative CD81 binding region 1 is not involved in CD81 binding

1 reference

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Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus

1 reference

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20 March 2017

Structural elucidation of critical residues involved in binding of human monoclonal antibodies to hepatitis C virus E2 envelope glycoprotein

1 reference

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Identification of a Broadly Cross-Reacting and Neutralizing Human Monoclonal Antibody Directed against the Hepatitis C Virus E2 Protein

1 reference

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Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus

1 reference

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The Neutralizing Activity of Anti-Hepatitis C Virus Antibodies Is Modulated by Specific Glycans on the E2 Envelope Protein

1 reference

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Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C

1 reference

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Immunogenic and Functional Organization of Hepatitis C Virus (HCV) Glycoprotein E2 on Infectious HCV Virions

1 reference

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Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding

1 reference

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Analysis of a Highly Flexible Conformational Immunogenic Domain A in Hepatitis C Virus E2

1 reference

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20 March 2017

Monoclonal Antibody AP33 Defines a Broadly Neutralizing Epitope on the Hepatitis C Virus E2 Envelope Glycoprotein

1 reference

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Robust hepatitis C virus infection in vitro

1 reference

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Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection

1 reference

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20 March 2017

In vitro assay for neutralizing antibody to hepatitis C virus: Evidence for broadly conserved neutralization epitopes

1 reference

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Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

1 reference

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Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes

1 reference

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20 March 2017

Efficient Replication of Hepatitis C Virus Genotype 1a RNAs in Cell Culture

1 reference

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Characterization of Low- and Very-Low-Density Hepatitis C Virus RNA-Containing Particles

1 reference

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20 March 2017

Mapping B-cell epitopes of hepatitis C virus E2 glycoprotein using human monoclonal antibodies from phage display libraries

1 reference

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Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes

1 reference

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Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor

1 reference

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Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81.

1 reference

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Binding of hepatitis C virus to CD81

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

1 reference

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Equilibrium centrifugation studies of hepatitis C virus: evidence for circulating immune complexes

1 reference

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Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses

1 reference

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Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus

1 reference

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Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

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Complete replication of hepatitis C virus in cell culture

1 reference

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Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy

1 reference

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CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells

1 reference

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Adaptive immune responses in acute and chronic hepatitis C virus infection

1 reference

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1 reference

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Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes

1 reference

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Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein

1 reference

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Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo

1 reference

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Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33.

1 reference

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Transmission in vitro of hepatitis C virus from persistently infected human B-cells to hepatoma cells by cell-to-cell contact

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Hepatitis C virus E2 has three immunogenic domains containing conformational epitopes with distinct properties and biological functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Neutralizing antibodies to hepatitis C virus (HCV) in immune globulins derived from anti-HCV-positive plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Recombinant human monoclonal antibodies against different conformational epitopes of the E2 envelope glycoprotein of hepatitis C virus that inhibit its interaction with CD81.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Efficacy of prophylactic gamma-globulin in preventing non-A, non-B post-transfusion hepatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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High titers of antibodies inhibiting the binding of envelope to human cells correlate with natural resolution of chronic hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Characterization of human monoclonal antibodies specific to the hepatitis C virus glycoprotein E2 with in vitro binding neutralization properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Human monoclonal antibodies that react with the E2 glycoprotein of hepatitis C virus and possess neutralizing activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2687388

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Structural features of envelope proteins on hepatitis C virus-like particles as determined by anti-envelope monoclonal antibodies and CD81 binding

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Effect of immune globulin on the prevention of experimental hepatitis C virus infection

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Hypervariable region of hepatitis C virus envelope glycoprotein (E2/NS1) in an agammaglobulinemic patient.

1 reference

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1 reference

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Hepatitis B immune globulin to prevent non-A, non-B post-transfusion hepatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19321602

12 December 2020

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10.1128/JVI.00248-09

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