(Q27552181)

English

Hsp90 cochaperone STI1 YOR027W

fungal protein found in Saccharomyces cerevisiae S288c

Hsp90 cochaperone STI1
STI1
YOR027W

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Statements

1 reference

25 May 2022

1 reference

10 December 2016

Tetratricopeptide-like helical domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P15705

Heat shock chaperonin-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tetratricopeptide repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tetratricopeptide repeat 1 family

1 reference

based on heuristic

inferred from protein domain or family

Tetratricopeptide repeat family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

A screen for RNA-binding proteins in yeast indicates dual functions for many enzymes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

determination method

IDA

ATPase inhibitor activity

1 reference

9 May 2019

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

determination method

IDA

Hsp70 protein binding

1 reference

9 May 2019

Sti1 Is a Novel Activator of the Ssa Proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

10 references

9 May 2019

Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

Cns1 is an essential protein associated with the hsp90 chaperone complex in Saccharomyces cerevisiae that can restore cyclophilin 40-dependent functions in cpr7Delta cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p).

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

determination method

IPI

Hsp90 protein binding

3 references

9 May 2019

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

1 reference

9 May 2019

In vivo analysis of the Hsp90 cochaperone Sti1 (p60)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

1 reference

9 May 2019

The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

determination method

IMP

protein targeting to mitochondrion

1 reference

9 May 2019

The cytosolic cochaperone Sti1 is relevant for mitochondrial biogenesis and morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

determination method

IMP

negative regulation of catalytic activity

1 reference

9 May 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15705

determination method

IEA

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

Saccharomyces Genome Database ID

1 reference

20 March 2022

(Q27552181)

Hsp90 cochaperone STI1 YOR027W

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