(Q27621351)

1

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E A Neidhardt

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T H Grossman

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T Ocain

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J Clardy

Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

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language of work or name

English

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publication date

15 January 2000

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published in

Structure

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volume

8

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issue

1

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page(s)

25-33

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cites work

1 reference

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7 January 2021

T-lymphocytes from AIDS patients are unable to synthesize ribonucleotides de novo in response to mitogenic stimulation. Impaired pyrimidine responses are already evident at early stages of HIV-1 infection

1 reference

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7 January 2021

Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans

1 reference

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7 January 2021

Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound

1 reference

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7 January 2021

Phase I safety and pharmacokinetic studies of brequinar sodium after single ascending oral doses in stable renal, hepatic, and cardiac allograft recipients

1 reference

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7 January 2021

Leflunomide, a novel immunomodulating drug, inhibits homotypic adhesion of peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis.

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7 January 2021

Leflunomide and malononitrilamides

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7 January 2021

Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group.

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7 January 2021

Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis

1 reference

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7 January 2021

Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts

1 reference

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7 January 2021

Cloning and sequencing of a human cDNA coding for dihydroorotate dehydrogenase by complementation of the corresponding yeast mutant

1 reference

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7 January 2021

Recombinant human dihydroorotate dehydrogenase: expression, purification, and characterization of a catalytically functional truncated enzyme

1 reference

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7 January 2021

The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis

1 reference

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7 January 2021

The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function

1 reference

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7 January 2021

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

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7 January 2021

Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme

1 reference

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7 January 2021

Histidine to alanine mutants of human dihydroorotate dehydrogenase. Identification of a brequinar-resistant mutant enzyme

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7 January 2021

Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection

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7 January 2021

The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis

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7 January 2021

Mechanistic studies on the bovine liver mitochondrial dihydroorotate dehydrogenase using kinetic deuterium isotope effects.

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7 January 2021

Low concentration of inducer favors production of active form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in Escherichia coli.

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7 January 2021

Preparation of selenomethionyl proteins for phase determination

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7 January 2021

The CCP4 suite: programs for protein crystallography

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7 January 2021

[37] Patterson superposition and ab initio phasing

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7 January 2021

Miscellaneous algorithms for density modification

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7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

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7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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7 January 2021

Efficient anisotropic refinement of macromolecular structures using FFT

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7 January 2021

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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7 January 2021

ALSCRIPT: a tool to format multiple sequence alignments

1 reference

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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7 January 2021

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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7 January 2021

10.1016/S0969-2126(00)00077-0

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

10673429

1 reference

Consolidated OpenCitations Corpus – April 2017