(Q27622522)

English

The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions

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scholarly article

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The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions (English)

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based on heuristic

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based on heuristic

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author name string

J A Huntington

1

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A McCoy

2

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K J Belzar

3

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X Y Pei

4

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P G Gettins

5

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R W Carrell

6

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language of work or name

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publication date

19 May 2000

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Journal of Biological Chemistry

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275

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20

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15377-83

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On the size of the active site in proteases. I. Papain

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21 January 2018

Biological implications of a 3 A structure of dimeric antithrombin

1 reference

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The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

1 reference

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Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

1 reference

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Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

1 reference

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Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

1 reference

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Structural basis for serpin inhibitor activity

1 reference

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Crystal structure of uncleaved ovalbumin at 1.95 A resolution

1 reference

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Inhibitory conformation of the reactive loop of alpha 1-antitrypsin

1 reference

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The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

1 reference

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The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function

1 reference

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The structure of active serpin 1K from Manduca sexta

1 reference

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The anticoagulant activation of antithrombin by heparin

1 reference

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Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity

1 reference

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Mechanism of heparin activation of antithrombin. Evidence for reactive center loop preinsertion with expulsion upon heparin binding

1 reference

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Conformational conversion of antithrombin to a fully activated substrate of factor Xa without need for heparin

1 reference

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Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin

1 reference

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AMoRe: an automated package for molecular replacement

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

1 reference

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

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An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

1 reference

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Raster3D Version 2.0. A program for photorealistic molecular graphics

1 reference

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The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

1 reference

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21 January 2018

Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.

1 reference

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21 January 2018

A unique trisaccharide sequence in heparin mediates the early step of antithrombin III activation

1 reference

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21 January 2018

The role of Arg46 and Arg47 of antithrombin in heparin binding.

1 reference

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21 January 2018

Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures.

1 reference

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21 January 2018

Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop

1 reference

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A mechanism for heparin-induced potentiation of antithrombin III

1 reference

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21 January 2018

Identifiers

10.1074/JBC.275.20.15377

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