(Q27625103)

English

Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate

scientific article published in June 2000

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scholarly article

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8 November 2019

Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10873853%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

crystal structure

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7

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8 November 2019

author name string

N Ostermann

1

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8 November 2019

I Schlichting

2

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8 November 2019

R Brundiers

3

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8 November 2019

M Konrad

4

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8 November 2019

J Reinstein

5

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8 November 2019

T Veit

6

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8 November 2019

A Lavie

8

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8 November 2019

publication date

1 June 2000

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8 November 2019

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8 November 2019

8

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8 November 2019

6

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8 November 2019

629-642

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8 November 2019

Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast

1 reference

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1 reference

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The P-loop--a common motif in ATP- and GTP-binding proteins

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Modifying Human Thymidylate Kinase to Potentiate Azidothymidine Activation

1 reference

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Escherichia coli thymidylate kinase: molecular cloning, nucleotide sequence, and genetic organization of the corresponding tmk locus

1 reference

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Mouse ascites Sarcoma 180 thymidylate kinase. General properties, kinetic analysis, and inhibition studies

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Kinetic and thermodynamic characterizations of yeast guanylate kinase.

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Movie of the structural changes during a catalytic cycle of nucleoside monophosphate kinases

1 reference

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7 January 2021

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High-resolution structures of adenylate kinase from yeast ligated with inhibitor Ap5A, showing the pathway of phosphoryl transfer

1 reference

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7 January 2021

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Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 A: implications for water-mediated specificity

1 reference

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7 January 2021

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Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative

1 reference

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7 January 2021

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Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation

1 reference

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The closed conformation of a highly flexible protein: the structure of E. coli adenylate kinase with bound AMP and AMPPNP

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Signaling mechanistics: aluminum fluoride for molecule of the year

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X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution

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Structure of the complex of adenylate kinase from Escherichia coli with the inhibitor P1,P5-di(adenosine-5'-)pentaphosphate

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7 January 2021

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Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 A resolution. A model for a catalytic transition state

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Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

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The CCP4 suite: programs for protein crystallography

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Raster3D Version 2.0. A program for photorealistic molecular graphics

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Identifiers

10.1016/S0969-2126(00)00149-0

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10873853%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

PubMed publication ID

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10873853%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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