(Q27626637)

2

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D J Cowley

3

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C Guenet

4

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J P Merly

5

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M Teufel

6

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V Saudek

Structure-based design of novel, urea-containing FKBP12 inhibitors.

7

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language of work or name

English

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publication date

September 2000

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published in

FEBS Journal

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volume

267

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issue

17

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page(s)

5342-55

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cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

32-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

FK506 and the role of immunophilins in nerve regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Neural actions of immunophilin ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Natural abundance nitrogen-15 NMR by enhanced heteronuclear spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Overcoming the overlap problem in the assignment of 1H NMR spectra of larger proteins by use of three-dimensional heteronuclear 1H-15N Hartmann-Hahn-multiple quantum coherence and nuclear Overhauser-multiple quantum coherence spectroscopy: applicati

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

An improved double-tuned and isotope-filtered pulse scheme based on a pulsed field gradient and a wide-band inversion shaped pulse

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Gradient-enhanced TOCSY experiments with improved sensitivity and solvent suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Simple, distortion-free homonuclear spectra of peptides and nucleic acids in water using excitation sculpting

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

AURELIA, a program for computer-aided analysis of multidimensional NMR spectra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Calculation of protein structures with ambiguous distance restraints. Automated assignment of ambiguous NOE crosspeaks and disulphide connectivities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Determination of three-dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array of atoms. Circumventing problems associated with folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Floating stereospecific assignment revisited: application to an 18 kDa protein and comparison with J-coupling data

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Spectral density function mapping using 15N relaxation data exclusively

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Theory and practice of nuclear spin relaxation in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

NMR spectroscopy in structure-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Characterization of the backbone dynamics of an anti-digoxin antibody VL domain by inverse detected 1H-15N NMR: comparisons with X-ray data for the Fab.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Three-dimensional structure of the immunophilin-like domain of FKBP59 in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

MOLMOL: a program for display and analysis of macromolecular structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

The importance of not saturating water in protein NMR. Application to sensitivity enhancement and NOE measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

The discovery of steroids and other novel FKBP inhibitors using a molecular docking program

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

15N NMR relaxation studies of the FK506 binding protein: backbone dynamics of the uncomplexed receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Conformation of two non-immunosuppressive FK506 analogs when bound to FKBP by isotope-filtered NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Correlation of Backbone Amide and Aliphatic Side-Chain Resonances in 13C/15N-Enriched Proteins by Isotropic Mixing of 13C Magnetization

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Model building and refinement practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Internal mobility in the partially folded DNA binding and dimerization domains of GAL4: NMR analysis of the N-H spectral density functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Protein backbone dynamics revealed by quasi spectral density function analysis of amide N-15 nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

High Throughput Scintillation Proximity Assay for the Identification of FKBP-12 Ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X

Chemical shift as a probe of molecular interfaces: NMR studies of DNA binding by the three amino-terminal zinc finger domains from transcription factor IIIA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01551.X