(Q27640254)

6 July 2017

title

Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site (English)

1 reference

6 July 2017

1

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Pascale Marchot

4

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Pascale Marchot

object named as

Pascale Marchot

4

1 reference

ORCID Public Data File 2021

author name string

Palmer Taylor

2

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6 July 2017

Zoran Radić

3

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6 July 2017

Yves Bourne

1

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6 July 2017

language of work or name

English

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publication date

1 January 2003

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6 July 2017

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6 July 2017

volume

22

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6 July 2017

issue

1

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6 July 2017

page(s)

1-12

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Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase

6 July 2017

cites work

1 reference

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20 March 2017

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Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

20 March 2017

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Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution

20 March 2017

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20 March 2017

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"Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase

20 March 2017

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Crystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in a tetrameric assembly

20 March 2017

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Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A

20 March 2017

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Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

20 March 2017

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Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex

20 March 2017

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Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins

20 March 2017

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Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

20 March 2017

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1.9-A resolution structure of fasciculin 1, an anti-acetylcholinesterase toxin from green mamba snake venom

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase

20 March 2017

1 reference

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Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

20 March 2017

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Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

20 March 2017

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Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center

20 March 2017

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Entering a new phase: using solvent halide ions in protein structure determination.

20 March 2017

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Soluble monomeric acetylcholinesterase from mouse: expression, purification, and crystallization in complex with fasciculin.

29 September 2017

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Cloning and expression of acetylcholinesterase from Bungarus fasciatus venom. A new type of cooh-terminal domain; involvement of a positively charged residue in the peripheral site

29 September 2017

1 reference

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Fasciculins, anticholinesterase toxins from the venom of the green mamba Dendroaspis angusticeps.

29 September 2017

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Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species

29 September 2017

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Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites.

29 September 2017

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Expression and activity of mutants of fasciculin, a peptidic acetylcholinesterase inhibitor from mamba venom.

2 June 2018

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Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

2 June 2018

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Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.

2 June 2018

1 reference

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Allosteric Control of Acetylcholinesterase Catalysis by Fasciculin

2 June 2018

1 reference

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Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite.

2 June 2018

1 reference

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Fluorescence energy transfer on acetylcholinesterase: spatial relationship between peripheral site and active center

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Spectroscopic studies on acetylcholinesterase: influence of peripheral-site occupation on active-center conformation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Site selectivity of fluorescent bisquaternary phenanthridinium ligands for acetylcholinesterase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Kinetic, equilibrium and spectroscopic studies on cation association at the active center of acetylcholinesterase: topographic distinction between trimethyl and trimethylammonium sites

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Ligand-induced conformational changes in acetylcholinesterase investigated with fluorescent phosphonates

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys69-Cys96, of mouse acetylcholinesterase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Peripheral site ligands accelerate inhibition of acetylcholinesterase by neutral organophosphates

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Reversibly bound and covalently attached ligands induce conformational changes in the omega loop, Cys69-Cys96, of mouse acetylcholinesterase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica 1 1Edited by R. Huber

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

The adhesion function on acetylcholinesterase is located at the peripheral anionic site

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Binding of 125I-fasciculin to rat brain acetylcholinesterase. The complex still binds diisopropyl fluorophosphate

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140045

Acetylthiocholine binds to asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway

27 November 2018

1 reference

12 December 2020

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Effects of Mg2+ and Ca2+ on soluble and membrane-bound acetylcholinesterase from Electrophorus electricus

1 reference

12 December 2020

Relative binding sites of pharmacologically active ligands on bovine erythrocyte acetylcholinesterase

1 reference

12 December 2020

Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs

1 reference

12 December 2020

Different effects of two peripheral anionic site-binding ligands on acetylcholinesterase active-site gorge topography revealed by electron paramagnetic resonance

1 reference

12 December 2020

Fasciculin 2 Binds to the Peripheral Site on Acetylcholinesterase and Inhibits Substrate Hydrolysis by Slowing a Step Involving Proton Transfer during Enzyme Acylation

1 reference

12 December 2020

Differential effects of "peripheral" site ligands on Torpedo and chicken acetylcholinesterase

1 reference

12 December 2020

Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/CDG005

1 reference

OpenCitations bibliographic resource ID

6 July 2017

4301062

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

6 July 2017

1 reference