(Q27641333)

English

Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis

scientific article (publication date: 8 August 2003)

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scholarly article

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Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis (English)

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crystal structure

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Tomohisa Kuzuyama

object named as

Tomohisa Kuzuyama

2

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Shigeyuki Yokoyama

object named as

Shigeyuki Yokoyama

5

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Seiki Kuramitsu

4

object named as

Seiki Kuramitsu

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Jeremy R.H. Tame

7

object named as

Jeremy R H Tame

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8

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Sam-Yong Park

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author name string

Takashi Wada

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Shinya Satoh

3

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Satoru Unzai

6

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language of work or name

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publication date

8 August 2003

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Journal of Biological Chemistry

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278

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32

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30022-7

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Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units.

1 reference

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Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate

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Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis

1 reference

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LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis

1 reference

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Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein

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Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

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Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

1 reference

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Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol kinase

1 reference

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Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato

1 reference

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Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step

1 reference

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Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis

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Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily

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1H-15N heteronuclear NMR studies of Escherichia coli thioredoxin in samples isotopically labeled by residue type.

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Processing of X-ray diffraction data collected in oscillation mode

1 reference

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Automated MAD and MIR structure solution

1 reference

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Maximum-likelihood density modification using pattern recognition of structural motifs

1 reference

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The CCP4 suite: programs for protein crystallography

1 reference

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PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

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A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis

1 reference

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Mapping the protein universe

1 reference

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The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease

1 reference

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Structural basis for the catalysis and substrate specificity of homoserine kinase

1 reference

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Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease

1 reference

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21 January 2018

Identification of catalytic residues in human mevalonate kinase

1 reference

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Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation

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Identification and functional characterization of an active-site lysine in mevalonate kinase

1 reference

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Ion-pairs in proteins

1 reference

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Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily

1 reference

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Site-directed mutagenesis identifies catalytic residues in the active site of Escherichia coli phosphofructokinase

1 reference

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