(Q27642266)

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Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design

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Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design (English)

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5

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object named as

Ruth Brenk

1

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object named as

Klaus Reuter

4

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Milton T Stubbs

object named as

Milton T Stubbs

2

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author name string

Andreas Heine

3

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publication date

6 October 2003

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4

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1066-77

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10

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Genes, enzymes and coenzymes of queuosine biosynthesis in procaryotes

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tRNA-guanine transglycosylase from Escherichia coli: molecular mechanism and role of aspartate 89.

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Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophile

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21 January 2018

Transfer ribonucleic acid guanine transglycosylase isolated from rat liver

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21 January 2018

Biosynthesis of archaeosine, a novel derivative of 7-deazaguanosine specific to archaeal tRNA, proceeds via a pathway involving base replacement on the tRNA polynucleotide chain

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21 January 2018

Crystal structure of archaeosine tRNA-guanine transglycosylase

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21 January 2018

Novel predicted RNA-binding domains associated with the translation machinery

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Alternative Tertiary Structure of tRNA for Recognition by a Posttranscriptional Modification Enzyme

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21 January 2018

Characterization of cDNA encoding the human tRNA-guanine transglycosylase (TGT) catalytic subunit

1 reference

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21 January 2018

The effect of queuosine on tRNA structure and function.

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21 January 2018

Increased expression of queuosine synthesizing enzyme, tRNA-guanine transglycosylase, and queuosine levels in tRNA of leukemic cells

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21 January 2018

vacC, a virulence-associated chromosomal locus of Shigella flexneri, is homologous to tgt, a gene encoding tRNA-guanine transglycosylase (Tgt) of Escherichia coli K-12

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21 January 2018

Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis

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De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinity

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A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase

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The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000.

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Sequence analysis and overexpression of the Zymomonas mobilis tgt gene encoding tRNA-guanine transglycosylase: purification and biochemical characterization of the enzyme.

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21 January 2018

The computer program LUDI: a new method for the de novo design of enzyme inhibitors

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21 January 2018

tRNA-guanine transglycosylase from Escherichia coli: gross tRNA structural requirements for recognition.

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Improved methods for building protein models in electron density maps and the location of errors in these models

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TopDraw: a sketchpad for protein structure topology cartoons

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21 January 2018

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1 reference

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21 January 2018

Slight sequence variations of a common fold explain the substrate specificities of tRNA-guanine transglycosylases from the three kingdoms

1 reference

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21 January 2018

Transfer RNA modification, temperature and DNA superhelicity have a common target in the regulatory network of the virulence of Shigella flexneri: the expression of the virF gene

1 reference

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21 January 2018

tRNA-guanine transglycosylase from Escherichia coli: structure-activity studies investigating the role of the aminomethyl substituent of the heterocyclic substrate PreQ1

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300644

21 January 2018

Purification, crystallization, and preliminary x-ray diffraction studies of tRNA-guanine transglycosylase from Zymomonas mobilis

1 reference

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21 January 2018

Implementation of molecular replacement in AMoRe

1 reference

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21 January 2018

Identifiers

10.1002/CBIC.200300644

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