(Q27642315)

English

Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin

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Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin (English)

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Tilman Schirmer

8

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Andrea Mozzarelli

5

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4

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Daniela De Biase

object named as

Daniela De Biase

2

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1

object named as

Paola Storici

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author name string

Francesco Bossa

3

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Caroline Peneff

6

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Richard B Silverman

7

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language of work or name

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publication date

2 January 2004

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Journal of Biological Chemistry

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279

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1

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363-73

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Protein structure of pig liver 4-aminobutyrate aminotransferase and comparison with a cDNA-deduced sequence.

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Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy.

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Effect of the convulsive agent 3-mercaptopropionic acid on the levels of GABA, other amino acids and glutamate decarboxylase in different regions of the rat brain

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Phosphate-Activated Glutaminase in Relation to Huntington's Disease and Agonal State

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Increased gamma-aminobutyrate aminotransferase activity in brain of patients with Alzheimer's disease.

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Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis.

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Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation

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A new class of GABA agonist

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Design of potential anticonvulsant agents: mechanistic classification of GABA aminotransferase inactivators

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4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain

1 reference

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Vigabatrin: a novel therapy for seizure disorders

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Visual field defects with vigabatrin: epidemiology and therapeutic implications

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Enzyme-induced inactivation of transminases by acetylenic and vinyl analogues of 4-aminobutyrate

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The in vivo inhibition of GABA-transaminase by gabaculine

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Active-site-directed irreversible inhibition of rat brain 4-aminobutyrate aminotransferase by ethanolamine O-sulphate in vitro and in vivo

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A novel strategy for the treatment of cocaine addiction

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Inhibitors of GABA metabolism

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The CCP4 suite: programs for protein crystallography

1 reference

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

1 reference

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Protein function in the crystal

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Linear dichroism of biological chromophores

1 reference

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Crystals of tryptophan indole-lyase and tyrosine phenol-lyase form stable quinonoid complexes

1 reference

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Kinetic studies of tryptophan synthetase. Interaction of substrates with the B subunit

1 reference

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nifU gene product from Azotobacter vinelandii is a homodimer that contains two identical [2Fe-2S] clusters.

1 reference

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21 January 2018

Iron-sulfur clusters: nature's modular, multipurpose structures

1 reference

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Crystal structure of human recombinant ornithine aminotransferase

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Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites

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Fe-S proteins in sensing and regulatory functions

1 reference

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Biotin synthase is a pyridoxal phosphate-dependent cysteine desulfurase

1 reference

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Identification of lysine 346 as a functionally important residue for pyridoxal 5'-phosphate binding and catalysis in lysine 2, 3-aminomutase from Bacillus subtilis

1 reference

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21 January 2018

Crystal structure of wild-type tryptophan synthase complexed with the natural substrate indole-3-glycerol phosphate

1 reference

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Kinetic and spectral properties of rabbit brain 4-aminobutyrate aminotransferase

1 reference

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X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase

1 reference

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Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase

1 reference

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Catalytic inhibition of γ-aminobutyric acid-α-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog

1 reference

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The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo

1 reference

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The Structure of Muscimol, a GABA Analogue of Restricted Conformation

1 reference

31 May 2024

https://opencitations.net/index/api/v1/citations/10.3891/ACTA.CHEM.SCAND.26-1298

Identifiers

10.1074/JBC.M305884200

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