(Q27642760)

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Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity

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Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity (English)

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crystal structure

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5

object named as

Hengming Ke

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author name string

Qing Huai

1

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Yudong Liu

2

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Sharron H Francis

3

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Jackie D Corbin

4

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language of work or name

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publication date

26 March 2004

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Journal of Biological Chemistry

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279

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13

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13095-101

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Molecular diversity of cyclic AMP signalling

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Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

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Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

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Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

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Processing of X-ray diffraction data collected in oscillation mode

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Identifiers

10.1074/JBC.M311556200

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