(Q27642926)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

title

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37) (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

author

Chrisostomos Prodromou

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Maruf M U Ali

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Philippe Meyer

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

author name string

S Mark Roe

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Cara K Vaughan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Barry Panaretou

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Peter W Piper

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Laurence H Pearl

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

language of work or name

English

0 references

publication date

1 January 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

volume

116

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

page(s)

87-98

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

17 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck).

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Physical interaction of mammalian CDC37 with CDK4

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

GHKL, an emergent ATPase/kinase superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Cdc37: a protein kinase chaperone?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

A new approach to protein fold recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

SCOP: a structural classification of proteins database for the investigation of sequences and structures

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Hsp90 inhibitors as novel cancer chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Mechanism of dimer formation of the 90-kDa heat-shock protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Structure, function, and mechanism of the Hsp90 molecular chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Assigning genomic sequences to CATH

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Heat-shock protein 90, a chaperone for folding and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Coordinated ATP hydrolysis by the Hsp90 dimer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

N-terminal residues regulate the catalytic efficiency of the Hsp90 ATPase cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Modulation of Akt kinase activity by binding to Hsp90

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

An approach to multi-copy search in molecular replacement

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Dissection of the contribution of individual domains to the ATPase mechanism of Hsp90.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Heat-shock protein hsp90 governs the activity of pp60v-src kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2901027-4

7 January 2021

10.1016/S0092-8674(03)01027-4

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

1072935

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14718169%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1072935

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1072935