(Q34124337)

31 July 2017

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title

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs (English)

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31 July 2017

1

Blagosklonny MV

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31 July 2017

language of work or name

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1 April 2002

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31 July 2017

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31 July 2017

volume

16

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31 July 2017

issue

4

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31 July 2017

page(s)

455-462

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Effect of anti-leukemic drugs on cell cycle of human leukemic blast cells in vivo.

31 July 2017

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

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7 January 2021

Activation of the cell death program by inhibition of proteasome function

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7 January 2021

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

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7 January 2021

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

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7 January 2021

Proteasome-dependent regulation of p21WAF1/CIP1 expression

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Regulation of p53 stability by Mdm2

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Mdm2 promotes the rapid degradation of p53

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

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7 January 2021

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

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The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

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7 January 2021

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

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7 January 2021

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

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7 January 2021

Geldanamycin induces ErbB-2 degradation by proteolytic fragmentation

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7 January 2021

Intracellular retention and degradation of the epidermal growth factor receptor, two distinct processes mediated by benzoquinone ansamycins

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7 January 2021

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

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7 January 2021

Hsp90-mediated folding of the lymphoid cell kinase p56lck

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Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

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Modulation of Akt kinase activity by binding to Hsp90

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Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

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7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

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7 January 2021

Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway

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7 January 2021

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

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7 January 2021

Anticancer drug targets: growth factors and growth factor signaling

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7 January 2021

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7 January 2021

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7 January 2021

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

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7 January 2021

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7 January 2021

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7 January 2021

Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus

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7 January 2021

Enhanced Cell Differentiation When RB Is Hypophosphorylated and Down-Regulated by Radicicol, a SRC-Kinase Inhibitor

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7 January 2021

Geldanamycin induces cell cycle arrest in K562 erythroleukemic cells

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7 January 2021

Sequence-dependent enhancement of paclitaxel toxicity in non-small cell lung cancer by 17-allylamino 17-demethoxygeldanamycin

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7 January 2021

Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.

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7 January 2021

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

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7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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7 January 2021

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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7 January 2021

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation.

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7 January 2021

In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

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7 January 2021

Unusual expression and localization of heat-shock proteins in human tumor cells

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402415

7 January 2021

Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402415

7 January 2021

Use of an antibody to target geldanamycin

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402415

7 January 2021

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

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7 January 2021

Radicicol and geldanamycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons

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7 January 2021

Induction of hsp 72/73 by herbimycin A, an inhibitor of transformation by tyrosine kinase oncogenes.

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7 January 2021

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402415

7 January 2021

Depletion of Raf-1 protooncogene by geldanamycin causes apoptosis in human luteinized granulosa cells

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402415

7 January 2021

Phase I and pharmacologic study of the alkylating agent modulator novobiocin in combination with high-dose chemotherapy for the treatment of metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402415

7 January 2021

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402415

7 January 2021

Don't stop for repairs in a war zone: Darwinian evolution unites genes and environment in cancer development

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402415

1 reference

Dimensions Publication ID

31 July 2017

1050811432

0 references

1 reference