(Q27643967)

1

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Daniel Rauh

2

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Charles Kung

3

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Cai-Hong Yun

4

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Qi-Wen Fan

5

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Haridas Rode

6

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Chao Zhang

7

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Michael J Eck

8

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William A Weiss

9

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Kevan M Shokat

Protein kinases--the major drug targets of the twenty-first century?

10

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publication date

April 2007

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published in

Nature Chemical Biology

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volume

3

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page(s)

229-38

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issue

4

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Features of selective kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Selective kinase inhibition by exploiting differential pathway sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Chemical genetic analysis of the time course of signal transduction by JNK

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Mechanism-based profiling of enzyme families

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Synthesis of AX7593, a quinazoline-derived photoaffinity probe for EGFR

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

A cell-permeable, activity-based probe for protein and lipid kinases

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Synthesis and activity of C11-modified wortmannin probes for PI3 kinase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Structural basis for selective inhibition of Src family kinases by PP1

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

A kinase sequence database: sequence alignments and family assignment

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

A chemical switch for inhibitor-sensitive alleles of any protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Structural bioinformatics-based design of selective, irreversible kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Mechanism of action of erbB tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Crystal structures of active SRC kinase domain complexes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Three-dimensional structure of the tyrosine kinase c-Src

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Fluorogenic and fluorescent labeling reagents with a benzofurazan skeleton

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Epidermal growth factor receptor: mechanisms of activation and signalling.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO866

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO866

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

3334887

1048722714

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3334887

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference