(Q27650299)

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Ninety-Nine Is Not Enough: Molecular Characterization of Inhibitor-Resistant Human Immunodeficiency Virus Type 1 Protease Mutants with Insertions in the Flap Region

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scholarly article

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Ninety-Nine Is Not Enough: Molecular Characterization of Inhibitor-Resistant Human Immunodeficiency Virus Type 1 Protease Mutants with Insertions in the Flap Region (English)

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10

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Milan Kožíšek

1

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Pavlína Řezáčová

3

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author name string

Klára Grantz Sasková

2

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Noortje M van Maarseveen

5

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Dorien De Jong

6

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Charles A Boucher

7

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Ron M Kagan

8

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Monique Nijhuis

9

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language of work or name

1 reference

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inferred from title

publication date

June 2008

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Journal of Virology

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82

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12

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5869-78

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Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains

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20 March 2017

Domain flexibility in retroviral proteases: structural implications for drug resistant mutations

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20 March 2017

Active human immunodeficiency virus protease is required for viral infectivity

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20 March 2017

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20 March 2017

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

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20 March 2017

Macromolecular TLS refinement in REFMAC at moderate resolutions

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20 March 2017

Principles of protein-protein interactions

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20 March 2017

A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism

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20 March 2017

Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites

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20 March 2017

Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors

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7 April 2017

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

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7 April 2017

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29 September 2017

Functional correlation between a novel amino acid insertion at codon 19 in the protease of human immunodeficiency virus type 1 and polymorphism in the p1/p6 Gag cleavage site in drug resistance and replication fitness

1 reference

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29 September 2017

Overcoming HIV drug resistance through rational drug design based on molecular, biochemical, and structural profiles of HIV resistance

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29 September 2017

From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease

1 reference

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29 September 2017

HIV-1 Protease and reverse-transcriptase mutations: correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance

1 reference

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29 September 2017

Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms

1 reference

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29 September 2017

Rare one and two amino acid inserts adjacent to codon 103 of the HIV-1 reverse transcriptase (RT) affect susceptibility to non-nucleoside RT inhibitors.

1 reference

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29 September 2017

Determining and overcoming resistance to HIV protease inhibitors.

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29 September 2017

R57K polymorphism in the human immunodeficiency virus type 1 protease as predictor of early virological failure in a cohort of antiretroviral-naive patients treated mostly with a nelfinavir-containing regimen

1 reference

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29 September 2017

Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments

1 reference

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29 September 2017

Emergence of resistance to protease inhibitor amprenavir in human immunodeficiency virus type 1-infected patients: selection of four alternative viral protease genotypes and influence of viral susceptibility to coadministered reverse transcriptase n

1 reference

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29 September 2017

Functional correlates of insertion mutations in the protease gene of human immunodeficiency virus type 1 isolates from patients

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29 September 2017

Genotypic and phenotypic resistance patterns of human immunodeficiency virus type 1 variants with insertions or deletions in the reverse transcriptase (RT): multicenter study of patients treated with RT inhibitors

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29 September 2017

Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients

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29 September 2017

Human immunodeficiency virus type 1 drug susceptibility determination by using recombinant viruses generated from patient sera tested in a cell-killing assay

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29 September 2017

Increasing prevalence of HIV-1 protease inhibitor-associated mutations correlates with long-term non-suppressive protease inhibitor treatment.

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2 June 2018

Systematic mutational analysis of the active-site threonine of HIV-1 proteinase: rethinking the "fireman's grip" hypothesis

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2 June 2018

Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug.

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2 June 2018

Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure

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2 June 2018

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17 The kinetics of reversible tight-binding inhibition

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2 June 2018

An increase in viral replicative capacity drives the evolution of protease inhibitor-resistant human immunodeficiency virus type 1 in the absence of drugs

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27 November 2018

Amino acid insertions at position 35 of HIV-1 protease interfere with virus replication without modifying antiviral drug susceptibility.

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Clinical validation of atazanavir/ritonavir genotypic resistance score in protease inhibitor-experienced patients

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27 November 2018

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18400858

12 December 2020

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1 reference

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1 reference

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based on heuristic

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Identifiers

10.1128/JVI.02325-07

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