(Q27650760)

English

Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: INSIGHTS INTO NUCLEOTIDE SPECIFICITY, DIMERIZATION, AND cGMP-DEPENDENT CONFORMATIONAL CHANGE

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scholarly article

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Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: INSIGHTS INTO NUCLEOTIDE SPECIFICITY, DIMERIZATION, AND cGMP-DEPENDENT CONFORMATIONAL CHANGE (English)

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Phosphodiesterase 5A, cGMP-specific

1 reference

GOA release 2020-03-11

solution structure

1 reference

based on heuristic

inferred from title

Monica R. Sekharan

3

object named as

Monica R Sekharan

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Joseph A. Beavo

7

object named as

Joseph A Beavo

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author name string

Clemens C Heikaus

1

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Joseph R Stout

2

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Catherine M Eakin

4

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Ponni Rajagopal

5

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Peter S Brzovic

6

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Rachel E Klevit

8

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language of work or name

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publication date

15 August 2008

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Journal of Biological Chemistry

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283

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22749-59

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33

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Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP

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20 March 2017

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

SWISS-MODEL: An automated protein homology-modeling server

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

NMR View: A computer program for the visualization and analysis of NMR data

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20 March 2017

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

Refinement of protein structures in explicit solvent

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

Protein backbone angle restraints from searching a database for chemical shift and sequence homology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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20 March 2017

Torsion angle dynamics for NMR structure calculation with the new program DYANA

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

Structural basis for the activity of drugs that inhibit phosphodiesterases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

1 reference

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20 March 2017

Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

20 March 2017

Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

29 September 2017

Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

29 September 2017

GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

29 September 2017

Cyclic GMP phosphodiesterases and regulation of smooth muscle function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

29 September 2017

GAF domains: cyclic nucleotides come full circle

1 reference

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29 September 2017

TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

29 September 2017

The GAF domain: an evolutionary link between diverse phototransducing proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

29 September 2017

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

29 September 2017

Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

29 September 2017

Structure and function studies of the cGMP-stimulated phosphodiesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504876

2 June 2018

Cyclic nucleotide research -- still expanding after half a century

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801577200

21 January 2018

On-demand IC351 (Cialis) enhances erectile function in patients with erectile dysfunction

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https://api.crossref.org/works/10.1074%2FJBC.M801577200

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A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801577200

21 January 2018

Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801577200

21 January 2018

Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801577200

21 January 2018

A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801577200

21 January 2018

Molecular organization of bovine rod cGMP-phosphodiesterase 6.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801577200

21 January 2018

Protein Identification and Analysis Tools on the ExPASy Server

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801577200

21 January 2018

The oral efficacy of vardenafil hydrochloride for inducing penile erection in a conscious rabbit model

1 reference

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27 November 2018

Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18534985

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Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding phosphodiesterases. A putative NKXnD motif for cGMP binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/18534985

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Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18534985

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Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18534985

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Characterization of the tandem GAF domain of human phosphodiesterase 5 using a cyanobacterial adenylyl cyclase as a reporter enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/18534985

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inferred from PubMed ID database lookup

Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange Site-Directed Mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18534985

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of an active, monomeric catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18534985

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Backbone 1H, 13C, and 15N resonance assignment of the 46 kDa dimeric GAF A domain of phosphodiesterase 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/18534985

12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18534985

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inferred from PubMed ID database lookup

A subset of GAF domains are evolutionarily conserved sodium sensors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18534985

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M801577200

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