(Q27652817)

English

Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors

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scholarly article

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Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors (English)

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crystal structure

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protein structure

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author name string

Matthew S Kelker

1

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Rebecca Page

2

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Wolfgang Peti

3

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language of work or name

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publication date

9 January 2009

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number of pages

11

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based on heuristic

inferred from page(s)

Journal of Molecular Biology

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385

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11-21

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1

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Molecular biology of cantharidin in cancer cells

1 reference

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

1 reference

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Structure of the protein phosphatase 2A holoenzyme

1 reference

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Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

1 reference

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Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1

1 reference

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20 March 2017

Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1

1 reference

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20 March 2017

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

1 reference

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20 March 2017

Likelihood-enhanced fast translation functions

1 reference

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Coot: model-building tools for molecular graphics

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

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20 March 2017

Automated refinement of protein models

1 reference

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The CCP4 suite: programs for protein crystallography

1 reference

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

1 reference

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

2 references

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29 September 2017

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1 reference

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20 March 2017

Molecular enzymology underlying regulation of protein phosphatase-1 by natural toxins

1 reference

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Protein phosphatase 1--targeted in many directions

1 reference

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20 March 2017

Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins

1 reference

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Natural products as a robust source of new drugs and drug leads: past successes and present day issues

1 reference

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1 reference

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29 September 2017

Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

1 reference

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Strategies to maximize heterologous protein expression in Escherichia coli with minimal cost

1 reference

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29 September 2017

Protein phosphatase inhibition: structure based design. Towards new therapeutic agents

1 reference

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29 September 2017

Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity

1 reference

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29 September 2017

The microcystins and nodularins: cyclic polypeptide inhibitors of PP1 and PP2A.

1 reference

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29 September 2017

Okadaic acid: the archetypal serine/threonine protein phosphatase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652124

29 September 2017

Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies

1 reference

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Medical uses of mylabris in ancient China and recent studies

1 reference

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29 September 2017

The design, synthesis, and biological evaluation of analogues of the serine-threonine protein phosphatase 1 and 2A selective inhibitor microcystin LA: rational modifications imparting PP1 selectivity

1 reference

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2 June 2018

Different moieties of tautomycin involved in protein phosphatase inhibition and induction of apoptosis.

1 reference

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2 June 2018

A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.

1 reference

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Belizeanic acid: a potent protein phosphatase 1 inhibitor belonging to the okadaic acid class, with an unusual skeleton.

1 reference

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27 November 2018

Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding

1 reference

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27 November 2018

A new model of the tautomycin-PP1 complex that is not analogous to the corresponding okadaic acid structure

1 reference

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27 November 2018

The selective inhibition of phosphatases by natural toxins: the anhydride domain of tautomycin is not a primary factor in controlling PP1/PP2A selectivity

1 reference

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27 November 2018

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1 reference

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27 November 2018

Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A.

1 reference

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27 November 2018

Combinatorial control of protein phosphatase-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18992256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18992256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/18992256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new antibiotic, tautomycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18992256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of type 1 protein (serine/threonine) phosphatases by microcystin-Sepharose affinity chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/18992256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine-272 is involved in the inhibition of protein phosphatase-1 by multiple toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18992256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JMB.2008.10.053

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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