(Q27654045)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19273847%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

title

Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography (English)

1 reference

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23 January 2020

main subject

X-ray crystallography

0 references

author

Takashi Ohhara

2

1 reference

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23 January 2020

Nobuo Okazaki

6

1 reference

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23 January 2020

Shigeki Arai

7

1 reference

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23 January 2020

Hiroyoshi Matsumura

10

1 reference

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23 January 2020

Kazufumi Takano

13

1 reference

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23 January 2020

author name string

Motoyasu Adachi

1

1 reference

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23 January 2020

Kazuo Kurihara

3

1 reference

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23 January 2020

Taro Tamada

4

1 reference

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23 January 2020

Eijiro Honjo

5

1 reference

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23 January 2020

Yoshinari Shoyama

8

1 reference

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23 January 2020

Kaname Kimura

9

1 reference

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23 January 2020

Shigeru Sugiyama

11

1 reference

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23 January 2020

Hiroaki Adachi

12

1 reference

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23 January 2020

Yusuke Mori

14

1 reference

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23 January 2020

Koushi Hidaka

15

1 reference

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23 January 2020

Tooru Kimura

16

1 reference

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23 January 2020

Yoshio Hayashi

17

1 reference

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23 January 2020

Yoshiaki Kiso

18

1 reference

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23 January 2020

Ryota Kuroki

19

1 reference

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23 January 2020

language of work or name

English

0 references

publication date

9 March 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19273847%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

23 January 2020

published in

1 reference

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23 January 2020

volume

106

1 reference

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23 January 2020

issue

12

1 reference

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23 January 2020

page(s)

4641-4646

1 reference

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X-ray structure of HIV-1 protease in situ product complex

23 January 2020

cites work

1 reference

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Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site

20 March 2017

1 reference

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The Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-ray Diffraction

20 March 2017

1 reference

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Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism

20 March 2017

1 reference

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Caught in the Act: The 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate †

20 March 2017

1 reference

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AIDS — The First 20 Years

20 March 2017

1 reference

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Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Inhibition and catalytic mechanism of HIV-1 aspartic protease

20 March 2017

1 reference

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Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors

20 March 2017

1 reference

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Active human immunodeficiency virus protease is required for viral infectivity

20 March 2017

1 reference

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SHELXL: high-resolution refinement

20 March 2017

1 reference

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PHENIX: building new software for automated crystallographic structure determination

20 March 2017

2 references

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20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

22 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

20 March 2017

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HIV-1 protease: mechanism and drug discovery

22 April 2017

1 reference

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Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Small dipeptide-based HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic

20 March 2017

1 reference

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A low-barrier hydrogen bond in the catalytic triad of serine proteases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Viral dynamics in human immunodeficiency virus type 1 infection

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Neutron protein crystallography: current status and a brighter future

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Prospects for atomic resolution and neutron crystallography in drug design.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Follow the protons: a low-barrier hydrogen bond unifies the mechanisms of the aspartic proteases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Inhibitors of HIV-1 protease: a major success of structure-assisted drug design

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere

29 September 2017

1 reference

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Low-barrier hydrogen bonds and enzymic catalysis

29 September 2017

1 reference

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Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor

29 September 2017

1 reference

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An 11-kDa form of human immunodeficiency virus protease expressed in Escherichia coli is sufficient for enzymatic activity

29 September 2017

1 reference

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Retroviral reverse transcriptases: error frequencies and mutagenesis

29 September 2017

1 reference

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Crystallization and preliminary neutron diffraction studies of HIV-1 protease cocrystallized with inhibitor KNI-272.

29 September 2017

1 reference

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Catalysis and linear free energy relationships in aspartic proteases

2 June 2018

1 reference

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The role of hydrogen bonding in the enzymatic reaction catalyzed by HIV-1 protease

2 June 2018

1 reference

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The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties.

2 June 2018

1 reference

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Human immunodeficiency virus-1 protease. 1. Initial velocity studies and kinetic characterization of reaction intermediates by 18O isotope exchange

2 June 2018

1 reference

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Solution NMR evidence that the HIV-1 protease catalytic aspartyl groups have different ionization states in the complex formed with the asymmetric drug KNI-272.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0809400106

Ab initio molecular dynamics-based assignment of the protonation state of pepstatin A/HIV-1 protease cleavage site

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0809400106

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0809400106

Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660780

Hydration in proteins observed by high-resolution neutron crystallography

27 November 2018

1 reference

12 December 2020

A new neutron single-crystal diffractometer dedicated for biological macromolecules (BIX-4)

1 reference

12 December 2020

Binding free energy contributions of interfacial waters in HIV-1 protease/inhibitor complexes

1 reference

12 December 2020

Ionization states of the catalytic residues in HIV-1 protease

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0809400106

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19273847%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

ADS bibcode

2009PNAS..106.4641A

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19273847%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PubMed publication ID

19273847

2 references