(Q35171885)

6 August 2017

title

Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate (English)

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6 August 2017

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3

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6 August 2017

Elizabeth E Howell

6

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Paul Langan

object named as

Paul Langan

2

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author name string

Brad Bennett

1

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6 August 2017

Marat Mustyakimov

4

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6 August 2017

Benno Schoenborn

5

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6 August 2017

Chris Dealwis

7

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6 August 2017

language of work or name

English

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publication date

27 November 2006

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Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

published in

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6 August 2017

volume

103

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6 August 2017

issue

49

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6 August 2017

page(s)

18493-18498

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Effects of co-operative ligand binding on protein amide NH hydrogen exchange

6 August 2017

cites work

1 reference

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Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase

28 July 2018

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Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis

28 July 2018

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Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.

28 July 2018

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The 15-K neutron structure of saccharide-free concanavalin A.

28 July 2018

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Neutron crystallographic study on rubredoxin from Pyrococcus furiosus by BIX-3, a single-crystal diffractometer for biomacromolecules

28 July 2018

1 reference

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Mass spectrometry on hydrogen/deuterium exchange of dihydrofolate reductase: effects of ligand binding.

28 July 2018

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Structure, dynamics, and catalytic function of dihydrofolate reductase

28 July 2018

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Atom depth in protein structure and function

28 July 2018

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Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics

28 July 2018

1 reference

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Preorganization and protein dynamics in enzyme catalysis

28 July 2018

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Network of coupled promoting motions in enzyme catalysis

28 July 2018

1 reference

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A neutron Laue diffraction study of endothiapepsin: implications for the aspartic proteinase mechanism

28 July 2018

1 reference

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Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism

28 July 2018

1 reference

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Residue depth: a novel parameter for the analysis of protein structure and stability.

28 July 2018

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Quasi-Laue neutron-diffraction study of the water arrangement in crystals of triclinic hen egg-white lysozyme

28 July 2018

1 reference

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Hydrogen exchange and protein folding.

28 July 2018

1 reference

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Hydrogen exchange studies of protein structure

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Neutron Laue diffractometry with an imaging plate provides an effective data collection regime for neutron protein crystallography

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Understanding water: molecular dynamics simulations of myoglobin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

28 July 2018

1 reference

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How do mutations at phenylalanine-153 and isoleucine-155 partially suppress the effects of the aspartate-27-->serine mutation in Escherichia coli dihydrofolate reductase?

28 July 2018

1 reference

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Role of the active-site carboxylate in dihydrofolate reductase: kinetic and spectroscopic studies of the aspartate 26-->asparagine mutant of the Lactobacillus casei enzyme

28 July 2018

1 reference

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Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Molecular basis for nonadditive mutational effects in Escherichia coli dihydrofolate reductase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Kinetic mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Active site of RNase: neutron diffraction study of a complex with uridine vanadate, a transition-state analog

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Protonated state of methotrexate, trimethoprim, and pyrimethamine bound to dihydrofolate reductase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Environment and exposure to solvent of protein atoms. Lysozyme and insulin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Water structure in vitamin B12 coenzyme crystals. I. Analysis of the neutron and x-ray solvent densities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

13C NMR studies of complexes of Escherichia coli dihydrofolate reductase formed with methotrexate and with folic acid

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Preliminary neutron diffraction studies of Escherichia coli dihydrofolate reductase bound to the anticancer drug methotrexate

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

Amide-proton exchange of water-soluble proteins of different structural classes studied at the submolecular level by infrared spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

Protein dynamics investigated by the neutron diffraction-hydrogen exchange technique.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

DPX: for the analysis of the protein core

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

The pH-dependence of the binding of dihydrofolate and substrate analogues to dihydrofolate reductase from Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

Consideration of the pH-dependent inhibition of dihydrofolate reductase by methotrexate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

Protein crystallography with spallation neutrons

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1664550

Nuclear magnetic resonance study of the state of protonation of inhibitors bound to mutant dihydrofolate reductase lacking the active-site carboxyl

27 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

Direct Measurement of the pKaof Aspartic Acid 26 inLactobacillus caseiDihydrofolate Reductase: Implications for the Catalytic Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

Neutron diffraction identifies His 57 as the catalytic base in trypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

Neutron Diffraction Analysis of Myoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0604977103

Carbon-13 nuclear magnetic resonance study of protonation of methotrexate and aminopterin bound to dihydrofolate reductase

21 January 2018

1 reference

12 December 2020

Crystallization of a large single crystal of cubic insulin for neutron protein crystallography

1 reference

12 December 2020

Ligand-induced structural constraints in human dihydrofolate reductase revealed by peptide-specific antibodies

1 reference

12 December 2020

Site-directed deletion mutants of a carboxyl-terminal region of human dihydrofolate reductase

1 reference

12 December 2020

A comparison of neutron diffraction and molecular dynamics structures: hydroxyl group and water molecule orientations in trypsin

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0604977103

1 reference

6 August 2017

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6 August 2017

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