(Q27654050)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

title

GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Daan van Aalten

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

author name string

Vladimir S Borodkin

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Marianne Schimpl

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

language of work or name

English

0 references

publication date

13 May 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

volume

420

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

page(s)

221-227

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 2.5 Generic

23 January 2020

copyright license

start time

25 July 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

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Chemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell Death

20 March 2017

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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

20 March 2017

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Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

20 March 2017

1 reference

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GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels

20 March 2017

1 reference

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Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis

20 March 2017

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Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease

20 March 2017

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Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

An evolving hierarchical family classification for glycosyltransferases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Biochemical consequences of mutations causing the GM2 gangliosidoses

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

The hexosamine signaling pathway: deciphering the "O-GlcNAc code"

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone secretion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Structural and sequence-based classification of glycoside hydrolases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Molecular mechanisms of O-GlcNAcylation.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Protein ubiquitination is modulated by O-GlcNAc glycosylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

O-GlcNAc modification in diabetes and Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

O-glycosylation of the tail domain of neurofilament protein M in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (ALS).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

O-Linked N-Acetylglucosamine and Cancer: Messages from the Glycosylation of C-Myc

29 September 2017

1 reference

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O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar

29 September 2017

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Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

29 September 2017

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Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

29 September 2017

1 reference

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Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.

29 September 2017

1 reference

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Nagstatin, a new inhibitor of N-acetyl-beta-D-glucosaminidase, produced by Streptomyces amakusaensis MG846-fF3. Taxonomy, production, isolation, physico-chemical properties and biological activities

29 September 2017

1 reference

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Elevated expression of O-GlcNAc-modified proteins and O-GlcNAc transferase in corneas of diabetic Goto-Kakizaki rats

29 September 2017

1 reference

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O-linked N-acetylglucosamine is upregulated in Alzheimer brains.

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

N-acetylglucosaminono-1,5-lactone oxime and the corresponding (phenylcarbamoyl)oxime. Novel and potent inhibitors of beta-N-acetylglucosaminidase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

The structure of nagstatin, a new inhibitor of N-acetyl-beta-D-glucosaminidase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

O-GlcNAc modification: a nutritional sensor that modulates proteasome function

2 June 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090110

Antisense glutaminase inhibition modifies the O-GlcNAc pattern and flux through the hexosamine pathway in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090110

Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090110

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090110

Distinctive inhibition of O-GlcNAcase isoforms by an alpha-GlcNAc thiolsulfonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090110

A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090110

Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090110

Reduction of O-linked N-acetylglucosamine-modified assembly protein-3 in Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691177

An O-GlcNAcase-specific inhibitor and substrate engineered by the extension of the N-acetyl moiety

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19275764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19275764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19275764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1042/BJ20090110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19275764%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference