(Q27650997)

Matthew S Macauley

2

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David J Vocadlo

David J Vocadlo

11

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Keith A. Stubbs

Keith A Stubbs

8

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Gideon Davies

Gideon J Davies

10

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author name string

Scott A Yuzwa

1

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Julia E Heinonen

3

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Xiaoyang Shan

4

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Rebecca J Dennis

5

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Garrett E Whitworth

7

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Ernest J McEachern

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques.

9

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publication date

August 2008

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published in

Nature Chemical Biology

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volume

4

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issue

8

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page(s)

483-90

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Neurodegenerative tauopathies

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Reciprocity between O-GlcNAc and O-phosphate on the carboxyl terminal domain of RNA polymerase II.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Cell signaling, the essential role of O-GlcNAc!

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

An O-GlcNAcase-specific inhibitor and substrate engineered by the extension of the N-acetyl moiety

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Tautomeric modification of GlcNAc-thiazoline

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

N-acetylglucosaminono-1,5-lactone oxime and the corresponding (phenylcarbamoyl)oxime. Novel and potent inhibitors of beta-N-acetylglucosaminidase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

NAG-thiazoline, An N -Acetyl-β-hexosaminidase Inhibitor That Implicates Acetamido Participation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Stereochemistry of chitin hydrolysis by a plant chitinase/lysozyme and X-ray structure of a complex with allosamidin: evidence for substrate assisted catalysis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Characterization of a mouse monoclonal antibody specific for O-linked N-acetylglucosamine

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Coot: model-building tools for molecular graphics

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.96

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.96

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1286903

1050435297

0 references

Fatcat ID

release_lkrtauz4jngubebosd4n4vw4lm

0 references

1286903

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference