(Q27655292)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19396179%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

A new screening assay for allosteric inhibitors of cSrc (English)

1 reference

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26 January 2020

1 reference

7

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26 January 2020

author name string

Jeffrey R Simard

1

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26 January 2020

Sabine Klüter

2

1 reference

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26 January 2020

Christian Grütter

3

1 reference

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26 January 2020

Matthäus Getlik

4

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26 January 2020

Matthias Rabiller

5

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26 January 2020

Haridas B Rode

6

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26 January 2020

publication date

26 April 2009

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26 January 2020

published in

Nature Chemical Biology

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26 January 2020

volume

5

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26 January 2020

page(s)

394-396

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26 January 2020

issue

6

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Small-molecule inhibitors binding to protein kinases. Part I: exceptions from the traditional pharmacophore approach of type I inhibition

26 January 2020

cites work

1 reference

12 December 2020

1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors

1 reference

12 December 2020

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

1 reference

12 December 2020

Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)

1 reference

12 December 2020

Classifying protein kinase structures guides use of ligand-selectivity profiles to predict inactive conformations: structure of lck/imatinib complex

1 reference

12 December 2020

Small Molecule Recognition of c-Src via the Imatinib-Binding Conformation

1 reference

12 December 2020

A renaissance for SRC

1 reference

12 December 2020

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

1 reference

12 December 2020

Strategies to overcome resistance to targeted protein kinase inhibitors

1 reference

12 December 2020

Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR

1 reference

12 December 2020

Targeting cancer with small molecule kinase inhibitors

1 reference

12 December 2020

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

12 December 2020

Drug-target residence time and its implications for lead optimization

1 reference

12 December 2020

Rational design of inhibitors that bind to inactive kinase conformations

1 reference

12 December 2020

Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate

1 reference

12 December 2020

The discovery of receptor tyrosine kinases: targets for cancer therapy

1 reference

12 December 2020

Allosteric inhibitors of Bcr-abl-dependent cell proliferation

1 reference

12 December 2020

A Src-like inactive conformation in the abl tyrosine kinase domain

1 reference

12 December 2020

Small-molecule inhibitors binding to protein kinase. Part II: the novel pharmacophore approach of type II and type III inhibition

1 reference

12 December 2020

c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty

1 reference

12 December 2020

A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.162

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19396179%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

26 January 2020

0 references

1 reference