(Q27657139)

English

Molecular Basis of Substrate Promiscuity for the SAM-Dependent O -Methyltransferase NcsB1, Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin

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scholarly article

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Molecular Basis of Substrate Promiscuity for the SAM-Dependent O -Methyltransferase NcsB1, Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin (English)

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author name string

Heather A Cooke

1

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Elizabeth L Guenther

2

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Yinggang Luo

3

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Ben Shen

4

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Steven D Bruner

5

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language of work or name

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publication date

13 October 2009

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48

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40

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9590-8

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1 reference

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20 March 2017

Phasercrystallographic software

1 reference

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20 March 2017

Version 1.2 of the Crystallography and NMR system

1 reference

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20 March 2017

The CCP4 suite: programs for protein crystallography

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

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The calicheamicin gene cluster and its iterative type I enediyne PKS

1 reference

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The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases

1 reference

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Sequence-specific, strand-selective, and directional binding of neocarzinostatin chromophore to oligodeoxyribonucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500170

20 March 2017

Many paths to methyltransfer: a chronicle of convergence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500170

7 April 2017

SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold

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1 reference

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Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin

1 reference

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29 September 2017

A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis

1 reference

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29 September 2017

A note on difficult structure alignment problems.

1 reference

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29 September 2017

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1 reference

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Crystallographic refinement of ligand complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500170

29 September 2017

Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus.

1 reference

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Enediyne Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents

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29 September 2017

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1 reference

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On distance and similarity in fold space

1 reference

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27 November 2018

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1 reference

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27 November 2018

Biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

https://pubmed.ncbi.nlm.nih.gov/19702337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic ligands for apo-neocarzinostatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19702337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19702337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/19702337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism and base specificity of DNA Breakage in intact cells by neocarzinostatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19702337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neocarzinostatin chromophore binds to deoxyribonucleic acid by intercalation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19702337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI901257Q

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