(Q27662971)

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Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations

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scholarly article

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Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations (English)

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6

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Andrea Scozzafava

4

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Claudiu T Supuran

5

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author name string

Jason Wagner

1

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Balendu Sankara Avvaru

2

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Arthur H Robbins

3

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language of work or name

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publication date

15 July 2010

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Bioorganic & Medicinal Chemistry

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18

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14

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4873-8

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Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule

1 reference

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20 March 2017

Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins

1 reference

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20 March 2017

Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma

1 reference

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20 March 2017

High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design

1 reference

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20 March 2017

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

1 reference

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20 March 2017

Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors

1 reference

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20 March 2017

Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II

1 reference

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20 March 2017

Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study

1 reference

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20 March 2017

Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism

1 reference

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20 March 2017

Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition

1 reference

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20 March 2017

Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells

1 reference

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1 reference

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The finer things in X-ray diffraction data collection

2 references

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20 March 2017

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29 September 2017

Carbonic anhydrase inhibitors

2 references

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20 March 2017

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7 April 2017

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

1 reference

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20 March 2017

Production of active human carbonic anhydrase II in E. coli

1 reference

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20 March 2017

The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C

1 reference

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20 March 2017

Prophylactic low-dose acetazolamide reduces the incidence and severity of acute mountain sickness

1 reference

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29 September 2017

Carbonic anhydrase inhibitors: inhibition of Plasmodium falciparum carbonic anhydrase with aromatic/heterocyclic sulfonamides-in vitro and in vivo studies

1 reference

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29 September 2017

Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs?

1 reference

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29 September 2017

Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides

1 reference

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29 September 2017

The alpha-carbonic anhydrase from the malaria parasite and its inhibition

1 reference

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29 September 2017

Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.

1 reference

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29 September 2017

Malarial parasite carbonic anhydrase and its inhibitors

1 reference

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29 September 2017

Carbonic anhydrases as targets for medicinal chemistry

1 reference

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29 September 2017

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

1 reference

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29 September 2017

Carbonic anhydrases: current state of the art, therapeutic applications and future prospects

1 reference

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29 September 2017

Carbon-13 nuclear magnetic resonance probe of active-site ionizations in human carbonic anhydrase B

1 reference

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29 September 2017

Carbonic anhydrase inhibitors

1 reference

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27 November 2018

Carbonic anhydrase inhibitors: two-prong versus mono-prong inhibitors of isoforms I, II, IX, and XII exemplified by photochromic cis-1,2-alpha-dithienylethene derivatives

1 reference

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27 November 2018

Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid

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27 November 2018

Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols

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27 November 2018

Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).

1 reference

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27 November 2018

Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.

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27 November 2018

Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.

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27 November 2018

Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?

1 reference

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27 November 2018

Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.

1 reference

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27 November 2018

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1 reference

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27 November 2018

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Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity

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Carbonic anhydrase inhibitors. Water-soluble, topically effective intraocular pressure lowering agents derived from isonicotinic acid and aromatic/heterocyclic sulfonamides: is the tail more important than the ring?

1 reference

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12 December 2020

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Carbonic Anhydrase Inhibitors. Synthesis of Water-Soluble, Topically Effective, Intraocular Pressure-Lowering Aromatic/Heterocyclic Sulfonamides Containing Cationic or Anionic Moieties: Is the Tail More Important than the Ring?1

1 reference

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12 December 2020

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Carbonic Anhydrase Inhibitors: Hypoxia-Activatable Sulfonamides Incorporating Disulfide Bonds that Target the Tumor-Associated Isoform IX†

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https://pubmed.ncbi.nlm.nih.gov/20598552

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Carbonic Anhydrase Inhibitors: Clash with Ala65 as a Means for Designing Inhibitors with Low Affinity for the Ubiquitous Isozyme II, Exemplified by the Crystal Structure of the Topiramate Sulfamide Analogue†

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Identifiers

10.1016/J.BMC.2010.06.028

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