(Q27664075)

2

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Takuji Oyama

3

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Kanako Maebara

4

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Rinna Nakamori

5

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Kosuke Morikawa

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

6

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language of work or name

English

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publication date

6 October 2010

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published in

The EMBO Journal

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volume

29

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issue

19

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page(s)

3395-407

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cites work

1 reference

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Structural basis for the activation of PPARgamma by oxidized fatty acids

20 March 2017

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Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

20 March 2017

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Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands

20 March 2017

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Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design

20 March 2017

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Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

20 March 2017

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Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids

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Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms

20 March 2017

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Partial agonists activate PPARgamma using a helix 12 independent mechanism

20 March 2017

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

20 March 2017

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Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

20 March 2017

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Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

20 March 2017

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Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family

20 March 2017

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Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

20 March 2017

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A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation

20 March 2017

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

20 March 2017

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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

20 March 2017

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Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

22 April 2017

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Amine oxidase substrates mimic several of the insulin effects on adipocyte differentiation in 3T3 F442A cells

22 April 2017

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Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

20 March 2017

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Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

20 March 2017

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

7 April 2017

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PPARs and the complex journey to obesity

7 April 2017

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The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

7 April 2017

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A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

7 April 2017

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15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

7 April 2017

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Proline cis/trans-isomerase Pin1 regulates peroxisome proliferator-activated receptor gamma activity through the direct binding to the activation function-1 domain

7 April 2017

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Size and shape of protein molecules at the nanometer level determined by sedimentation, gel filtration, and electron microscopy.

29 September 2017

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Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas

29 September 2017

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Thiazolidinedione-induced skeletal fragility--mechanisms and implications

29 September 2017

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Pulmonary hypertension: therapeutic targets within the serotonin system.

29 September 2017

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Genes implicated in serotonergic and dopaminergic functioning predict BMI categories

29 September 2017

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Thiazolidinediones as anti-inflammatory and anti-atherogenic agents

29 September 2017

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The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.

29 September 2017

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The serotonin signaling system: from basic understanding to drug development for functional GI disorders

29 September 2017

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Serotonin and its role in colonic function and in gastrointestinal disorders

29 September 2017

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The many faces of PPARgamma

29 September 2017

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Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators

29 September 2017

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PPARs: therapeutic targets for metabolic disease

29 September 2017

1 reference

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Depression in diabetic patients: the relationship between mood and glycemic control

29 September 2017

1 reference

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Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor gamma ligand

29 September 2017

1 reference

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Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma.

29 September 2017

1 reference

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Mechanism of the nuclear receptor molecular switch

29 September 2017

1 reference

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The role of peroxisome proliferator-activated receptor gamma in colon cancer and inflammatory bowel disease

29 September 2017

1 reference

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Activation of nuclear receptors: a perspective from structural genomics

29 September 2017

1 reference

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Nuclear receptors. I. PPAR gamma in the gastrointestinal tract: gain or pain?

29 September 2017

1 reference

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T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities

29 September 2017

1 reference

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PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism.

29 September 2017

1 reference

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Autoregulation of the human liver X receptor alpha promoter

29 September 2017

1 reference

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Binding of ligands and activation of transcription by nuclear receptors.

29 September 2017

1 reference

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The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs (NSAIDs)

29 September 2017

1 reference

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Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957204

Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957204

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957204

A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957204

Activators of the nuclear receptor PPARgamma enhance colon polyp formation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957204

Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957204

Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.197

Maternal serotonin influences cardiac function in adult offspring.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.197

Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.197

Rational discovery of a novel interface for a coactivator in the peroxisome proliferator-activated receptor gamma: theoretical implications of impairment in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.197

Dopamine induces ERK activation in renal epithelial cells through H2O2 produced by monoamine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.197

Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957204

Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13-Reductase Complex Reveals the Structural Basis of Broad Spectrum Indomethacin Efficacy

27 November 2018

1 reference

12 December 2020

Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology

1 reference

12 December 2020

Structure of full-length PPARgamma-RXRalpha: a snapshot of a functional complex?

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Differentiation and reversal of malignant changes in colon cancer through PPARgamma

1 reference

12 December 2020

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2010.197

1 reference

release_twwwk3cbcrhzrmbtgkxv2vgxga

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

20717101

1 reference