(Q27664141)

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Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors

scientific article published on July 30, 2010

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Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors (English)

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Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors (English)

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10.1016/J.BMCL.2010.07.102

https://api.crossref.org/works/10.1016/J.BMCL.2010.07.102

21 June 2024

author name string

Shuqun Lin

1

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John Hynes

3

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Sidney Pitt

4

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Rosemary Zhang

5

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Yi Fan

6

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Murray McKinnon

13

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James Trzaskos

14

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Katerina Leftheris

18

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Stephen T. Wrobleski

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20732813

21 June 2024

Arthur M. Doweyko

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20732813

21 June 2024

Kevin F. Kish

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20732813

21 June 2024

John S. Sack

9

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20732813

21 June 2024

Mary F. Malley

10

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20732813

21 June 2024

Susan E. Kiefer

11

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20732813

21 June 2024

John A. Newitt

12

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20732813

21 June 2024

Joel C. Barrish

15

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20732813

21 June 2024

John H. Dodd

16

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Europe PubMed Central

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21 June 2024

Gary L. Schieven

17

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20732813

21 June 2024

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publication date

1 October 2010

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30 July 2010

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Europe PubMed Central

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21 June 2024

full work available at URL

https://api.elsevier.com/content/article/PII:S0960894X10010711?httpAccept=text/xml

1 reference

10.1016/J.BMCL.2010.07.102

https://api.crossref.org/works/10.1016/J.BMCL.2010.07.102

21 June 2024

https://api.elsevier.com/content/article/PII:S0960894X10010711?httpAccept=text/plain

1 reference

10.1016/J.BMCL.2010.07.102

https://api.crossref.org/works/10.1016/J.BMCL.2010.07.102

21 June 2024

Bioorganic & Medicinal Chemistry Letters

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20

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19

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5864-8

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p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines.

1

1 reference

10.1016/J.BMCL.2010.07.102

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21 June 2024

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

2

1 reference

10.1016/J.BMCL.2010.07.102

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21 June 2024

Small molecule p38 inhibitors: novel structural features and advances from 2002-2005.

3

1 reference

10.1016/J.BMCL.2010.07.102

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21 June 2024

Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development

4

1 reference

10.1016/J.BMCL.2010.07.102

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21 June 2024

The discovery of novel chemotypes of p38 kinase inhibitors

5

1 reference

10.1016/J.BMCL.2010.07.102

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21 June 2024

The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor

7

1 reference

10.1016/J.BMCL.2010.07.102

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21 June 2024

Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors

8

1 reference

10.1016/J.BMCL.2010.07.102

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21 June 2024

A database study of nonbonded intramolecular sulfur-nucleophile contacts.

9

1 reference

10.1016/J.BMCL.2010.07.102

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21 June 2024

Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element

10

1 reference

10.1016/J.BMCL.2010.07.102

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Intramolecular nonbonded S...N interaction in rabeprazole

11

1 reference

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21 June 2024

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10.1016/J.BMCL.2010.07.102

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release_rp74xwta3vhxjhry27wi56msee

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