(Q27664292)

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Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 Carbapenemase

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Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 Carbapenemase (English)

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crystal structure

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Acinetobacter baumannii

1 reference

based on heuristic

inferred from title

Focco van den Akker

11

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5

object named as

Jared M Sampson

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Robert A Bonomo

12

object named as

Robert A Bonomo

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Christopher R Bethel

7

object named as

Christopher R Bethel

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8

object named as

Anne M Distler

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Sundar Ram Reddy Pagadala

10

object named as

Sundar Ram Reddy Pagadala

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14

object named as

John D Buynak

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Anjaneyulu Sheri

3

object named as

Anjaneyulu Sheri

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9

object named as

Sarah M Drawz

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author name string

German Bou

1

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Elena Santillana

2

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Alejandro Beceiro

4

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Matthew Kalp

6

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Antonio Romero

13

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language of work or name

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publication date

29 September 2010

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Journal of the American Chemical Society

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132

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38

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13320-31

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Three decades of beta-lactamase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Updated functional classification of beta-lactamases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Strategic Design of an Effective -Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Inhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Carbapenemases: the versatile beta-lactamases

1 reference

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20 March 2017

Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Comparison of -lactamases of classes A and D: 1.5-A crystallographic structure of the class D OXA-1 oxacillinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Critical involvement of a carbamylated lysine in catalytic function of class D -lactamases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Inhibition of class C beta-lactamases: structure of a reaction intermediate with a cephem sulfone

1 reference

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20 March 2017

The integration of macromolecular diffraction data

1 reference

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20 March 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

The CCP4 suite: programs for protein crystallography

1 reference

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20 March 2017

UCSF Chimera--a visualization system for exploratory research and analysis

1 reference

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20 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

20 March 2017

Unraveling hot spots in binding interfaces: progress and challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

7 April 2017

Penicillin sulfone inhibitors of class D beta-lactamases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

29 September 2017

Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

29 September 2017

Beta-lactamase inhibitors: the story so far.

1 reference

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29 September 2017

Diversity, epidemiology, and genetics of class D beta-lactamases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

29 September 2017

The clinical consequences of antimicrobial resistance

1 reference

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29 September 2017

beta-Lactamases- the Threat Renews

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

29 September 2017

AmpC beta-lactamases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

29 September 2017

Inhibition of OXA-1 beta-lactamase by penems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

29 September 2017

Extended-spectrum beta-lactamases in North America, 1987-2006.

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29 September 2017

Global challenge of multidrug-resistant Acinetobacter baumannii

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29 September 2017

Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center

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29 September 2017

Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium

1 reference

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29 September 2017

Understanding the longevity of the beta-lactam antibiotics and of antibiotic/beta-lactamase inhibitor combinations

1 reference

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29 September 2017

Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition

1 reference

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29 September 2017

Identification of a new allelic variant of the Acinetobacter baumannii cephalosporinase, ADC-7 beta-lactamase: defining a unique family of class C enzymes

1 reference

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29 September 2017

Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity

1 reference

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29 September 2017

The discovery and development of modified penicillin- and cephalosporin-derived beta-lactamase inhibitors

1 reference

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29 September 2017

Method for estimation of low outer membrane permeability to beta-lactam antibiotics

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29 September 2017

Inactivation of CMY-2 beta-lactamase by tazobactam: initial mass spectroscopic characterization

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29 September 2017

OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393087

29 September 2017

How beta-lactamases have driven pharmaceutical drug discovery. From mechanistic knowledge to clinical circumvention

1 reference

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29 September 2017

Mechanistic and clinical aspects of beta-lactam antibiotics and beta-lactamases.

1 reference

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29 September 2017

Class C beta-lactamases operate at the diffusion limit for turnover of their preferred cephalosporin substrates

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29 September 2017

The beta-lactamase cycle: a tale of selective pressure and bacterial ingenuity

1 reference

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29 September 2017

Mechanistic diversity of beta-lactamases

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29 September 2017

When drug inactivation renders the target irrelevant to antibiotic resistance: a case story with beta-lactams

1 reference

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29 September 2017

A complex mutant of TEM-1 beta-lactamase with mutations encountered in both IRT-4 and extended-spectrum TEM-15, produced by an Escherichia coli clinical isolate.

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29 September 2017

ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type

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29 September 2017

The structure of β-lactamases

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29 September 2017

Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene

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29 September 2017

Kinetic properties of four plasmid-mediated AmpC beta-lactamases

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A standard numbering scheme for the class A beta-lactamases

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2 June 2018

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27 November 2018

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27 November 2018

Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases

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The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors.

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27 November 2018

Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives

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27 November 2018

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.

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27 November 2018

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Letter: Synthesis of new beta-lactam antibiotics

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12 December 2020

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Automated analysis of enzyme inactivation phenomena. Application to beta-lactamases and DD-peptidases

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12 December 2020

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The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors

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https://pubmed.ncbi.nlm.nih.gov/20822105

12 December 2020

based on heuristic

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Outer membrane permeability of Acinetobacter calcoaceticus and its implication in antibiotic resistance

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12 December 2020

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12 December 2020

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The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors

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https://pubmed.ncbi.nlm.nih.gov/20822105

12 December 2020

based on heuristic

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12 December 2020

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Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor

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https://pubmed.ncbi.nlm.nih.gov/20822105

12 December 2020

based on heuristic

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Identifiers

10.1021/JA104092Z

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