(Q27665397)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20981014%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A (English)

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14 January 2020

1

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14 January 2020

Isao Kii

6

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14 January 2020

Takamitsu Hosoya

11

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14 January 2020

2

Yosuke Nonaka

1 reference

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14 January 2020

3

Toshiyasu Goto

1 reference

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14 January 2020

8

Teikichi Ikura

1 reference

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14 January 2020

12

Nobutoshi Ito

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14 January 2020

13

Masatoshi Hagiwara

1 reference

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14 January 2020

author name string

Eriko Ohnishi

4

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14 January 2020

Toshiyuki Hiramatsu

5

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14 January 2020

Miyo Yoshida

7

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14 January 2020

Hiroshi Onogi

9

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14 January 2020

Hiroshi Shibuya

10

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14 January 2020

language of work or name

English

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publication date

5 October 2010

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14 January 2020

published in

Nature Communications

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14 January 2020

volume

1

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14 January 2020

page(s)

86

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Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration

14 January 2020

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS1090

Increased dosage of DYRK1A and brain volumetric alterations in a YAC model of partial trisomy 21.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS1090

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS1090

Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.

21 January 2018

1 reference

12 December 2020

Utilization of host SR protein kinases and RNA-splicing machinery during viral replication

1 reference

12 December 2020

Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A).

1 reference

12 December 2020

Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases.

1 reference

12 December 2020

Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases

1 reference

12 December 2020

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

1 reference

12 December 2020

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

1 reference

12 December 2020

Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

1 reference

12 December 2020

The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development

1 reference

12 December 2020

Molecular basis of pharmacotherapies for cognition in Down syndrome

1 reference

12 December 2020

Manipulation of alternative splicing by a newly developed inhibitor of Clks

1 reference

12 December 2020

Phasercrystallographic software

1 reference

12 December 2020

Version 1.2 of the Crystallography and NMR system

1 reference

12 December 2020

Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation

1 reference

12 December 2020

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

1 reference

12 December 2020

Molecular targets of (-)-epigallocatechin-3-gallate (EGCG): specificity and interaction with membrane lipid rafts

1 reference

12 December 2020

An investigation on the central effects of harmine, harmaline and related beta-carbolines

1 reference

12 December 2020

Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development

1 reference

12 December 2020

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

1 reference

12 December 2020

Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction

1 reference

12 December 2020

Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitors

1 reference

12 December 2020

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

1 reference

12 December 2020

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

1 reference

12 December 2020

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

1 reference

12 December 2020

Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"

1 reference

12 December 2020

Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome

1 reference

12 December 2020

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

1 reference

12 December 2020

DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease

1 reference

12 December 2020

Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21

1 reference

12 December 2020

Inhibition of monoamine oxidase A by beta-carboline derivatives

1 reference

12 December 2020

The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

1 reference

12 December 2020

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

1 reference

12 December 2020

Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties

1 reference

12 December 2020

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

1 reference

12 December 2020

DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase

1 reference

12 December 2020

Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases

1 reference

12 December 2020

Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse

1 reference

12 December 2020

Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity.

1 reference

12 December 2020

Involvement of NLK and Sox11 in neural induction in Xenopus development

1 reference

12 December 2020

Epidemiology of Down syndrome

1 reference

12 December 2020

Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A

1 reference

12 December 2020

Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

1 reference

12 December 2020

A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

1 reference

12 December 2020

Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome

1 reference

12 December 2020

Down syndrome--recent progress and future prospects

1 reference

12 December 2020

DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects

1 reference

12 December 2020

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

1 reference

12 December 2020

The specificities of protein kinase inhibitors: an update

1 reference

12 December 2020

The challenge of Down syndrome

1 reference

12 December 2020

Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome.

1 reference

12 December 2020

The selectivity of protein kinase inhibitors: a further update

1 reference

12 December 2020

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

1 reference

12 December 2020

NFAT signaling: choreographing the social lives of cells

1 reference

12 December 2020

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS1090

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20981014%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

14 January 2020

ADS bibcode

2010NatCo...1...86O

0 references

1042962633

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017