(Q27665984)

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X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger

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scholarly article

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X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger (English)

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4

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1

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object named as

Patrick Masson

6

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ORCID Public Data File 2021

author name string

Eugenie Carletti

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Marielle Wandhammer

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Lawrence M Schopfer

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Oksana Lockridge

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language of work or name

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publication date

15 February 2011

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Biochemical Journal

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434

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1

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73-82

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Most efficient cocaine hydrolase designed by virtual screening of transition states

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Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning

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20 April 2017

The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger

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20 April 2017

1 reference

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20 April 2017

The CCP4 suite: programs for protein crystallography

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Refinement of macromolecular structures by the maximum-likelihood method

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Coot: model-building tools for molecular graphics

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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products

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20 April 2017

Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation

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20 April 2017

Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun

1 reference

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20 April 2017

Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase

1 reference

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20 April 2017

AlF3 mimics the transition state of protein phosphorylation in the crystal structure of nucleoside diphosphate kinase and MgADP

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20 April 2017

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MOLREP: an Automated Program for Molecular Replacement

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Enzyme (re)design: lessons from natural evolution and computation

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21 January 2018

Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis

1 reference

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21 January 2018

Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?

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21 January 2018

Development of diagnostics in the search for an explanation of aerotoxic syndrome

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21 January 2018

Structure, activities and biomedical applications of human butyrylcholinesterase

1 reference

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21 January 2018

Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: a Mathematically Based Toxicokinetic Model

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21 January 2018

Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review

1 reference

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21 January 2018

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters

1 reference

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21 January 2018

Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase.

1 reference

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21 January 2018

A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase.

1 reference

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21 January 2018

Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase.

1 reference

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21 January 2018

Butyrylcholinesterase and G116H, G116S, G117H, G117N, E197Q and G117H/E197Q mutants: a molecular dynamics study

1 reference

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21 January 2018

Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization

1 reference

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21 January 2018

Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging

1 reference

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21 January 2018

A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

1 reference

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21 January 2018

The effect of fluoride on the scavenging of organophosphates by human butyrylcholinesterase in buffer solutions and human plasma

1 reference

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21 January 2018

Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry

1 reference

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21 January 2018

Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad

1 reference

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21 January 2018

Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase.

1 reference

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21 January 2018

Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization

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21 January 2018

Comparative genomics: Insecticide resistance in mosquito vectors

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21 January 2018

A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and confers insecticide resistance on a blowfly

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21 January 2018

Signal transduction in bacteria

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21 January 2018

Focus on phosphohistidine.

1 reference

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21 January 2018

Aging mechanism of butyrylcholinesterase inhibited by an N-methyl analogue of tabun: implications of the trigonal-bipyramidal transition state rearrangement for the phosphylation or reactivation of cholinesterases

1 reference

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21 January 2018

Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesterase

1 reference

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21 January 2018

Fixation of the Two Tabun Isomers in Acetylcholinesterase: A QM/MM Study

1 reference

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21 January 2018

Identifiers

10.1042/BJ20101648

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