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Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine

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Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine (English)

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Plasmodium falciparum

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phosphoethanolamine N-methyltransferase

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11 September 2018

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3

Joseph M Jez

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author name string

Soon Goo Lee

series ordinal

1

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Tara D Alpert

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2

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language of work or name

English

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publication date

1 August 2012

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published in

Bioorganic & Medicinal Chemistry Letters

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volume

22

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issue

15

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page(s)

4990-3

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cites work

Structure and Reaction Mechanism of Phosphoethanolamine Methyltransferase from the Malaria Parasite Plasmodium falciparum

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Artemisinin Resistance in Plasmodium falciparum Malaria

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20 March 2017

A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation

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24 May 2017

Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus

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29 September 2017

Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy.

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29 September 2017

Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay

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29 September 2017

Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects.

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29 September 2017

Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans

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Structural basis for inhibition of histamine N-methyltransferase by diverse drugs

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Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum

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Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis

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27 November 2018

In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway

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27 November 2018

cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme

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27 November 2018

Antimalarial activity of compounds interfering with Plasmodium falciparum phospholipid metabolism: comparison between mono- and bisquaternary ammonium salts

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retrieved

12 December 2020

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Identifiers

DOI

10.1016/J.BMCL.2012.06.032

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PMC publication ID

3401361

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PubMed publication ID

22771008

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(Q27670659)

Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine

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