(Q27673244)

9

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Christian Krintel

object named as

Christian Krintel

1

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Jette S Kastrup

object named as

Jette S Kastrup

10

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author name string

Lars Olsen

3

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Maria T Kristensen

4

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Oriol de Barrios

5

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Peter Naur

6

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Pierre Francotte

7

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Bernard Pirotte

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

8

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language of work or name

English

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publication date

1 January 2012

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published in

Biochemical Journal

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volume

441

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issue

1

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page(s)

173-8

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cites work

1 reference

Mechanism of positive allosteric modulators acting on AMPA receptors

20 April 2017

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Mechanism of glutamate receptor desensitization

20 April 2017

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Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2

20 April 2017

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Probing the Allosteric Modulator Binding Site of GluR2 with Thiazide Derivatives

20 April 2017

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Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors

20 April 2017

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Molecular Mechanism of Flop Selectivity and Subsite Recognition for an AMPA Receptor Allosteric Modulator: Structures of GluA2 and GluA3 in Complexes with PEPA

20 April 2017

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A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies

20 April 2017

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Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

20 April 2017

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Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator

20 April 2017

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Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

20 April 2017

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Phasercrystallographic software

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Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

20 April 2017

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Coot: model-building tools for molecular graphics

20 April 2017

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

20 April 2017

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7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys

20 April 2017

1 reference

PHENIX: building new software for automated crystallographic structure determination

20 April 2017

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Rapid measurement of binding constants and heats of binding using a new titration calorimeter

20 April 2017

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Ionotropic glutamate receptors & CNS disorders.

20 April 2017

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Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

21 January 2018

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Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor

21 January 2018

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Do enthalpy and entropy distinguish first in class from best in class?

21 January 2018

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A molecular determinant for submillisecond desensitization in glutamate receptors

21 January 2018

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Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors

21 January 2018

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Exact analysis of competition ligand binding by displacement isothermal titration calorimetry

21 January 2018

1 reference

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Ring-Fused Thiadiazines as Core Structures for the Development of Potent AMPA Receptor Potentiators

21 January 2018

1 reference

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Allosteric potentiation by diazoxide of AMPA receptor currents and synaptic potentials

21 January 2018

1 reference

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Prediction of pH-dependent aqueous solubility of druglike molecules

21 January 2018

1 reference

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Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators

21 January 2018

1 reference

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4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propion

21 January 2018

1 reference

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Excavations in drug chirality: 1. Cyclothiazide

21 January 2018

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