(Q27674271)

21 June 2017

title

Structure of RdxA--an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori (English)

1 reference

21 June 2017

0 references

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1 reference

Marta Martínez-Júlvez

Vladimir Espinosa Angarica

1

0 references

Vladimir Espinosa Angarica

4

0 references

Adriana L. Rojas

Adriana L Rojas

2

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Marta Martínez-Júlvez

Marta Martínez-Júlvez

1

0 references

Igor Olekhnovich

Igor Olekhnovich

3

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author name string

Paul S Hoffman

5

1 reference

21 June 2017

Javier Sancho

6

1 reference

21 June 2017

language of work or name

English

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publication date

7 November 2012

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21 June 2017

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21 June 2017

volume

279

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21 June 2017

issue

23

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21 June 2017

page(s)

4306-4317

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NADH oxidase activity of Bacillus subtilis nitroreductase NfrA1: insight into its biological role

21 June 2017

cites work

1 reference

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Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

20 March 2017

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20 March 2017

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Structures of nitroreductase in three states: effects of inhibitor binding and reduction

20 March 2017

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The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution

20 March 2017

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Structure of a flavin-binding plant photoreceptor domain: Insights into light-mediated signal transduction

20 March 2017

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Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme

20 March 2017

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Dissecting the energetics of the apoflavodoxin-FMN complex

20 March 2017

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1.8 A crystal structure of the major NAD(P)H:FMN oxidoreductase of a bioluminescent bacterium, Vibrio fischeri: overall structure, cofactor and substrate-analog binding, and comparison with related flavoproteins

20 March 2017

1 reference

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

20 March 2017

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Dali server: conservation mapping in 3D

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

BALBES: a molecular-replacement pipeline

20 March 2017

1 reference

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The Buccaneer software for automated model building. 1. Tracing protein chains

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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Solvent content of protein crystals

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Protein dynamics governed by interfaces of high polarity and low packing density

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984].

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Reciprocal expression of integration host factor and HU in the developmental cycle and infectivity of Legionella pneumophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

An ortholog of OxyR in Legionella pneumophila is expressed postexponentially and negatively regulates the alkyl hydroperoxide reductase (ahpC2D) operon

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Reduction of polynitroaromatic compounds: the bacterial nitroreductases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Is the molecular basis of metronidazole resistance in microaerophilic organisms understood?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Salmonella typhimurium mutagenicity tester strains that overexpress oxygen-insensitive nitroreductases nfsA and nfsB.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Metronidazole activation is mutagenic and causes DNA fragmentation in Helicobacter pylori and in Escherichia coli containing a cloned H. pylori RdxA(+) (Nitroreductase) gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pylori

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Mechanisms of flavoprotein-catalyzed reactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Purification and characterization of an oxygen-insensitive NAD(P)H nitroreductase from Enterobacter cloacae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Ferredoxin-dependent reduction of nitroimidazole derivatives in drug-resistant and susceptible strains of Trichomonas vaginalis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504637

Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.

19 June 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12020

Flavin thermodynamics explain the oxygen insensitivity of enteric nitroreductases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12020

Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12020

Quantitative structure-activity relationships in two-electron reduction of nitroaromatic compounds by Enterobacter cloacae NAD(P)H:nitroreductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12020

Histidine residues at the N- and C-termini of alpha-helices: perturbed pKas and protein stability

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23039228

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two-electron reduction of nitroaromatic compounds by Enterobacter cloacae NAD(P)H nitroreductase: description of quantitative structure-activity relationships

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23039228

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/FEBS.12020

1 reference

21 June 2017

0 references

1 reference