(Q27674554)

2

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David Koes

3

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Grzegorz M Popowicz

4

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Carlos J Camacho

5

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Tad A Holak

6

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Alexander Dömling

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

7

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publication date

2 January 2012

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published in

ChemMedChem

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volume

7

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issue

1

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page(s)

49-52

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cites work

1 reference

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Fluorine in pharmaceuticals: looking beyond intuition

20 March 2017

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Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit

20 March 2017

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Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II

20 March 2017

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Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists

20 March 2017

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A critical assessment of docking programs and scoring functions

20 March 2017

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The p53-MDM2/MDMX axis - A chemotype perspective

7 April 2017

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Aromatic rings in chemical and biological recognition: energetics and structures

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The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious

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Aurora kinase inhibitors based on the imidazo[1,2-a]pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure

29 September 2017

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29 September 2017

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29 September 2017

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The many roles for fluorine in medicinal chemistry

29 September 2017

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Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?

29 September 2017

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Predicting and tuning physicochemical properties in lead optimization: amine basicities

29 September 2017

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Modern synthetic methods for fluorine-substituted target molecules

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Impact of chemical structure on quinolone potency, spectrum and side effects

29 September 2017

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Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.

29 September 2017

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1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity.

2 June 2018

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The enterococcus: a classic example of the impact of antimicrobial resistance on therapeutic options

2 June 2018

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Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

21 January 2018

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Ligand efficiency indices as guideposts for drug discovery.

21 January 2018

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Ligand Entropy in Gas-Phase, Upon Solvation and Protein Complexation. Fast Estimation with Quasi-Newton Hessian.

21 January 2018

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Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo

21 January 2018

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12 December 2020

Biomimetic Reductive Amination of Fluoro Aldehydes and Ketones via [1,3]-Proton Shift Reaction.(1) Scope and Limitations

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12 December 2020

Application of NMR in structural proteomics: screening for proteins amenable to structural analysis

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12 December 2020

Fluorine in medicinal chemistry

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12 December 2020

Fluorine-18 and medical imaging: Radiopharmaceuticals for positron emission tomography

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7 January 2021