(Q41861051)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

main subject

computational biology

1 reference

protein-protein interaction

inferred from title

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Michal Bista

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Michal Bista

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Alex Domling

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

Barbara Beck

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Stuti Srivastava

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Grzegorz M Popowicz

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Siglinde Wolf

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Yijun Huang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Tad A Holak

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

language of work or name

English

0 references

publication date

1 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

Angewandte Chemie International Edition

6 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

issue

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

page(s)

5352-5356

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

The rise of fragment-based drug discovery

6 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

ANCHOR: a web server and database for analysis of protein-protein interaction binding pockets for drug discovery

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

The Gewald multicomponent reaction.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Identification and characterization of the first small molecule inhibitor of MDMX

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Knowledge-based virtual screening: application to the MDM4/p53 protein-protein interaction

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Strategies for innovation in multicomponent reaction design

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Perspectives on NMR in drug discovery: a technique comes of age

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Emerging approaches for the syntheses of bicyclic imidazo[1,2-x]-heterocycles

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Hot spots--a review of the protein-protein interface determinant amino-acid residues

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Making "real" molecules in virtual space

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Recent developments in isocyanide based multicomponent reactions in applied chemistry

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

High-throughput screening of historic collections: observations on file size, biological targets, and file diversity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Anatomy of hot spots in protein interfaces

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Discovering high-affinity ligands for proteins: SAR by NMR

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Robust NMR screening for lead compounds using tryptophan-containing proteins.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Efficient C2 functionalisation of 2H-2-imidazolines.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Exploration of liquid and supercritical fluid chromatographic chiral separation and purification of Nutlin-3--a small molecule antagonist of MDM2.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Novel Multicomponent Reaction for the Combinatorial Synthesis of 2-Imidazolines

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772515

Charge distribution from a simple molecular orbital type calculation and non-bonding interaction terms in the force field MAB

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20575124

12 December 2020

inferred from PubMed ID database lookup

NMR structure of a complex between MDM2 and a small molecule inhibitor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20575124

12 December 2020

inferred from PubMed ID database lookup

An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20575124

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1002/ANIE.201001343

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20575124%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference