(Q27675149)

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Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 That Accelerates the Transition into the Latent Conformation

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Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 That Accelerates the Transition into the Latent Conformation (English)

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1 reference

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author name string

Ola Fjellström

1

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Johanna Deinum

2

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Tove Sjögren

3

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Carina Johansson

4

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Stefan Geschwindner

5

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Viveca Nerme

6

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Anne Legnehed

7

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Jane McPheat

8

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Karolina Olsson

9

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Cristian Bodin

10

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Amalia Paunovic

11

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David Gustafsson

12

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language of work or name

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publication date

11 January 2013

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Journal of Biological Chemistry

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288

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2

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873-85

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Crystal Structure of Plasminogen Activator Inhibitor-1 in an Active Conformation with Normal Thermodynamic Stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

Structural Basis for Recognition of Urokinase-type Plasminogen Activator by Plasminogen Activator Inhibitor-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

Structures of active and latent PAI-1: a possible stabilizing role for chloride ions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

REFMAC5 for the refinement of macromolecular crystal structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

Integration of macromolecular diffraction data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

Platelets retain high levels of active plasminogen activator inhibitor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

20 March 2017

Plasminogen activator inhibitor-1 (PAI-1): a key factor linking fibrinolysis and age-related subclinical and clinical conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

Biochemical properties of plasminogen activator inhibitor-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

New insights into the molecular mechanisms of the fibrinolytic system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

A peptide accelerating the conversion of plasminogen activator inhibitor-1 to an inactive latent state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

A deletion mutant of vitronectin lacking the somatomedin B domain exhibits residual plasminogen activator inhibitor-1-binding activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

Shape-shifting serpins--advantages of a mobile mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

Plasminogen activator inhibitor 1 (PAI-1) in its active conformation: crystallization and preliminary X-ray diffraction data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

Calcium-dependent stabilization of type I plasminogen activator inhibitor within platelet alpha-granules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

Serpin tertiary structure transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

29 September 2017

Characterization of a site on PAI-1 that binds to vitronectin outside of the somatomedin B domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

2 June 2018

Modulation of adipose tissue development by pharmacological inhibition of PAI-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

2 June 2018

Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

2 June 2018

Complex formation between plasminogen activator inhibitor 1 and vitronectin in purified systems and in plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

2 June 2018

Lysis of Platelet‐rich Thrombi: The Role of PAI–1a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

2 June 2018

Stability of plasminogen activator inhibitor 1 (PAI-1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

19 June 2018

Structural basis of latency in plasminogen activator inhibitor-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543036

19 June 2018

Interactions of plasminogen activator inhibitor-1 with vitronectin involve an extensive binding surface and induce mutual conformational rearrangements.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.371732

21 January 2018

Regulation of local availability of active tissue-type plasminogen activator in vivo in man.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.371732

21 January 2018

Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.371732

21 January 2018

A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.371732

21 January 2018

Identification of the binding site for a low-molecular-weight inhibitor of plasminogen activator inhibitor type 1 by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.371732

21 January 2018

The platelet-rich plasma clot: a standardized in-vitro clot formation protocol for investigations of sonothrombolysis under physiological flows.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.371732

21 January 2018

Accelerated conversion of human plasminogen activator inhibitor-1 to its latent form by antibody binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a pre-latent form of the serpin plasminogen activator inhibitor-1 with a detached beta-strand 1C

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterisation and reproducibility of a human ex vivo model of thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of inhibitors of plasminogen activator inhibitor-1: structure-activity study of 5-nitro-2-phenoxybenzoic acid derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of renal fibrin deposition in endotoxin-induced DIC through inhibition of PAI-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of N-terminal residues in plasminogen activator inhibitor 1 on its antibody induced latency transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of a conformational epitope on plasminogen activator inhibitor-1 by random mutagenesis. Implications for serpin function

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elucidation of the epitope of a latency-inducing antibody: identification of a new molecular target for PAI-1 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of the active to latent plasminogen activator inhibitor from human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amount of plasminogen, tissue-type plasminogen activator and plasminogen activator inhibitor type 1 in human thrombi and the relation to ex-vivo lysibility

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separation of active and inactive forms of recombinant human plasminogen activator inhibitor type 1 (PAI-1) expressed in Chinese hamster ovary cells: comparison with native human PAI-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasminogen activator inhibitor type-1 interacts exclusively with the proteinase domain of tissue plasminogen activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of fibrinolysis are elevated in atherosclerotic plaque

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Fab-fragment of a PAI-1 inhibiting antibody reduces thrombus size and restores blood flow in a rat model of arterial thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasminogen activator inhibitor-1 (PAI-1) content in platelets from healthy individuals genotyped for the 4G/5G polymorphism in the PAI-1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein movement during complex-formation between tissue plasminogen activator and plasminogen activator inhibitor-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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