(Q27675192)

1

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Allyn J Schoeffler

2

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Andreas Lingel

3

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J Michael Elliott

4

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Anna V Fedorova

5

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Anthony M Giannetti

6

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Kerry Zobel

7

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Brigitte Maurer

8

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Eugene Varfolomeev

9

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Ping Wu

10

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Heidi J A Wallweber

11

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Sarah G Hymowitz

12

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Kurt Deshayes

13

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Domagoj Vucic

14

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Wayne J Fairbrother

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

15

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language of work or name

English

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publication date

21 October 2011

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published in

Science

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volume

334

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issue

6054

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page(s)

376-80

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cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

Structural basis of IAP recognition by Smac/DIABLO

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

RING domain E3 ubiquitin ligases

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

Coot: model-building tools for molecular graphics

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1207862

IAP proteins: blocking the road to death's door

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

The inhibitor of apoptosis proteins as therapeutic targets in cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

The inhibitors of apoptosis (IAPs) as cancer targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

Promoting apoptosis as a strategy for cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

Small-molecule pan-IAP antagonists: a patent review

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

Assembling the building blocks: structure and function of inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

Protein identification using 20-minute Edman cycles and sequence mixture analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

PRIMUS: a Windows PC-based system for small-angle scattering data analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862

Determination of domain structure of proteins from X-ray solution scattering

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1207862