(Q27675616)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22090477%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor (English)

1 reference

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16 January 2020

author name string

Patrick C May

1

1 reference

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16 January 2020

Robert A Dean

2

1 reference

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16 January 2020

Stephen L Lowe

3

1 reference

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16 January 2020

Ferenc Martenyi

4

1 reference

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16 January 2020

Scott M Sheehan

5

1 reference

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16 January 2020

Leonard N Boggs

6

1 reference

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16 January 2020

Scott A Monk

7

1 reference

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16 January 2020

Brian M Mathes

8

1 reference

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16 January 2020

Dustin J Mergott

9

1 reference

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16 January 2020

Brian M Watson

10

1 reference

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16 January 2020

Stephanie L Stout

11

1 reference

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16 January 2020

David E Timm

12

1 reference

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16 January 2020

Elizabeth Smith Labell

13

1 reference

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16 January 2020

Celedon R Gonzales

14

1 reference

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16 January 2020

Masako Nakano

15

1 reference

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16 January 2020

Stanford S Jhee

16

1 reference

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16 January 2020

Mark Yen

17

1 reference

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16 January 2020

Larry Ereshefsky

18

1 reference

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16 January 2020

Terry D Lindstrom

19

1 reference

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16 January 2020

David O Calligaro

20

1 reference

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16 January 2020

Patrick J Cocke

21

1 reference

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16 January 2020

D Greg Hall

22

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16 January 2020

Stuart Friedrich

23

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16 January 2020

Martin Citron

24

1 reference

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16 January 2020

James E Audia

25

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16 January 2020

language of work or name

English

0 references

publication date

1 November 2011

1 reference

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16 January 2020

published in

Journal of Neuroscience

1 reference

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16 January 2020

volume

31

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16 January 2020

page(s)

16507-16516

1 reference

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16 January 2020

issue

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22090477%20AND%20SRC:MED&resulttype=core&format=json

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

16 January 2020

cites work

1 reference

12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

12 December 2020

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

1 reference

12 December 2020

Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets

1 reference

12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

12 December 2020

Axonal neuregulin-1 regulates myelin sheath thickness

1 reference

12 December 2020

Ligand efficiency: a useful metric for lead selection

1 reference

12 December 2020

Fragment-Based Drug Discovery

1 reference

12 December 2020

The CCP4 suite: programs for protein crystallography

1 reference

12 December 2020

Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.

1 reference

12 December 2020

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

1 reference

12 December 2020

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

1 reference

12 December 2020

Control of peripheral nerve myelination by the beta-secretase BACE1

1 reference

12 December 2020

Bace1 modulates myelination in the central and peripheral nervous system.

1 reference

12 December 2020

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

1 reference

12 December 2020

Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker.

1 reference

12 December 2020

BACE1 regulates voltage-gated sodium channels and neuronal activity

1 reference

12 December 2020

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

1 reference

12 December 2020

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

1 reference

12 December 2020

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

1 reference

12 December 2020

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

1 reference

12 December 2020

Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets

1 reference

12 December 2020

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

1 reference

12 December 2020

Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase

1 reference

12 December 2020

A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system

1 reference

12 December 2020

Features and development of Coot

1 reference

12 December 2020

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

1 reference

12 December 2020

Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability

1 reference

12 December 2020

Evidence that A beta 42 is the real culprit in Alzheimer's disease.

1 reference

12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

12 December 2020

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

12 December 2020

10.1523/JNEUROSCI.3647-11.2011

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

2190828

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22090477%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

2190828

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22090477%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

2 references

Consolidated OpenCitations Corpus – April 2017

2190828