(Q27675859)

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Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates

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Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates (English)

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5

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Apirat Chaikuad

2

object named as

Apirat Chaikuad

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6

object named as

Bernd Nidetzky

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3

object named as

Mario Klimacek

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Kathryn L Kavanagh

4

object named as

Kathryn L Kavanagh

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author name string

Sigrid Egger

1

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language of work or name

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publication date

13 January 2012

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Journal of Biological Chemistry

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287

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3

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2119-29

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Structural basis of cooperativity in human UDP-glucose dehydrogenase

1 reference

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20 March 2017

Structure of Burkholderia cepacia UDP-Glucose Dehydrogenase (UGD) BceC and Role of Tyr10 in Final Hydrolysis of UGD Thioester Intermediate

1 reference

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20 March 2017

Role of packing defects in the evolution of allostery and induced fit in human UDP-glucose dehydrogenase

1 reference

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20 March 2017

Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: a possible inhibition mechanism for the key enzyme in polymyxin resistance

1 reference

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20 March 2017

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase

1 reference

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20 March 2017

The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation

1 reference

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20 March 2017

Solving structures of protein complexes by molecular replacement with Phaser

1 reference

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Coot: model-building tools for molecular graphics

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

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20 March 2017

The CCP4 suite: programs for protein crystallography

1 reference

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20 March 2017

Integration of macromolecular diffraction data

1 reference

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20 March 2017

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

1 reference

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20 March 2017

Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations

1 reference

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20 March 2017

Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase

1 reference

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29 September 2017

Crystallographic evidence for active-site dynamics in the hydrolytic aldehyde dehydrogenases. Implications for the deacylation step of the catalyzed reaction.

1 reference

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29 September 2017

UDP-glucose dehydrogenase: structure and function of a potential drug target

1 reference

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29 September 2017

Characterization of human UDP-glucose dehydrogenase reveals critical catalytic roles for lysine 220 and aspartate 280.

1 reference

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29 September 2017

The first crystal structure of a thioacylenzyme intermediate in the ALDH family: new coenzyme conformation and relevance to catalysis.

1 reference

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29 September 2017

Active site residues and mechanism of UDP-glucose dehydrogenase

1 reference

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29 September 2017

The packing density in proteins: standard radii and volumes.

1 reference

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29 September 2017

Mechanisms of action of histidinol dehydrogenase and UDP-Glc dehydrogenase. Evidence that the half-reactions proceed on separate subunits

1 reference

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29 September 2017

Udpglucose dehydrogenase Kinetics and their mechanistic implications

1 reference

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29 September 2017

Half-of-the-sites reactivity of bovine liver uridine diphosphoglucose dehydrogenase toward iodoacetate and iodoacetamide

1 reference

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29 September 2017

Mechanism of action of uridine diphosphoglucose dehydrogenase. Evidence for a second reversible dehydrogenation step involving an essential thiol group

1 reference

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29 September 2017

UDP-glucose dehydrogenase: substrate binding stoichiometry and affinity

1 reference

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2 June 2018

Regulation of UDP-glucose dehydrogenase is sufficient to modulate hyaluronan production and release, control sulfated GAG synthesis, and promote chondrogenesis.

1 reference

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21 January 2018

Covalent Adduct Formation with a Mutated Enzyme: Evidence for a Thioester Intermediate in the Reaction Catalyzed by UDP-Glucose Dehydrogenase

1 reference

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21 January 2018

Properties and Kinetic Analysis of UDP-glucose Dehydrogenase from Group A Streptococci

1 reference

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21 January 2018

UDP-Glucose Analogues as Inhibitors and Mechanistic Probes of UDP-Glucose Dehydrogenase

1 reference

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21 January 2018

Mechanism of action of uridine diphoglucose dehydrogenase. Evidence for an essential lysine residue at the active site

1 reference

https://pubmed.ncbi.nlm.nih.gov/22123821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The stereospecificity of hydrogen abstraction by uridine diphosphoglucose dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22123821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanism of action of UDP-D-glucose dehydrogenase from beef liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/22123821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of action of uridine diphosphoglucose dehydrogenase. Uridine diphosphohexodialdoses as intermediates

1 reference

https://pubmed.ncbi.nlm.nih.gov/22123821

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.313015

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