(Q27675974)

1

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Disha Patel

2

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Chhaya Dharia

3

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Marc W Fromer

4

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Sameer Ahmed

5

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Yulia Frenkel

6

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R S K Vijayan

7

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J Thomas Eck

8

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William C Ho

9

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Kalyan Das

10

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Aaron J Shatkin

Journal of Medicinal Chemistry

11

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language of work or name

English

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publication date

11 April 2013

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published in

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volume

56

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issue

7

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page(s)

2738-46

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cites work

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HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism

20 March 2017

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Fragment screening and HIV therapeutics

20 March 2017

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 March 2017

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Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations

20 March 2017

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BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities

20 March 2017

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Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

20 March 2017

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The maximal affinity of ligands

20 March 2017

1 reference

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Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

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The molecular mechanism of stabilization of proteins by TMAO and its ability to counteract the effects of urea

20 March 2017

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

20 March 2017

1 reference

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Ligand efficiency: a useful metric for lead selection

20 March 2017

1 reference

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Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies

7 April 2017

1 reference

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Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 reverse transcriptase by fragment library screening.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

HIV-1 RT-associated RNase H function inhibitors: Recent advances in drug development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Halogen atoms in the modern medicinal chemistry: hints for the drug design.

29 September 2017

1 reference

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Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Solution characterization of [methyl-(13)C]methionine HIV-1 reverse transcriptase by NMR spectroscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Therapeutic potential of peptide motifs against HIV-1 reverse transcriptase and integrase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Fragment-based activity space: smaller is better

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Solution structural dynamics of HIV-1 reverse transcriptase heterodimer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Deconstruction of non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1 for exploration of the optimization landscape of fragments

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3906421

Prediction of biological activity for high-throughput screening using binary kernel discrimination.

27 November 2018

1 reference

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Fluorine-NMR competition binding experiments for high-throughput screening of large compound mixtures

27 November 2018

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12 December 2020

Fragment-based lead discovery

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12 December 2020

Fragment-based drug design - tools, practical approaches, and examples. Preface

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12 December 2020

Planar stacking interactions of arginine and aromatic side-chains in proteins

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12 December 2020