(Q30904604)

6 November 2017

1 reference

title

Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium (English)

1 reference

6 November 2017

1 reference

1 reference

Jürgen Bosch

11

0 references

Frederick S Buckner

20

object named as

Frederick S Buckner

1 reference

6 November 2017

Eric T Larson

13

1 reference

ORCID Public Data File 2021

Wim G J Hol

22

object named as

Wim G J Hol

1 reference

6 November 2017

Christophe L M J Verlinde

1

1 reference

6 November 2017

Erkang Fan

2

1 reference

6 November 2017

Sayaka Shibata

3

1 reference

6 November 2017

Zongsheng Zhang

4

1 reference

6 November 2017

Zhihua Sun

5

1 reference

6 November 2017

Wei Deng

6

1 reference

6 November 2017

Jennifer Ross

7

1 reference

6 November 2017

Jessica Kim

8

1 reference

6 November 2017

Liren Xiao

9

1 reference

6 November 2017

Tracy L Arakaki

10

1 reference

6 November 2017

Jonathan M Caruthers

12

1 reference

6 November 2017

Isolde Letrong

14

1 reference

6 November 2017

Alberto Napuli

15

1 reference

6 November 2017

Angela Kelly

16

1 reference

6 November 2017

Natasha Mueller

17

1 reference

6 November 2017

Frank Zucker

18

1 reference

6 November 2017

Wesley C Van Voorhis

19

1 reference

6 November 2017

Ethan A Merritt

21

1 reference

6 November 2017

1 January 2009

1 reference

Current Topics in Medicinal Chemistry

6 November 2017

1 reference

6 November 2017

9

1 reference

6 November 2017

18

1 reference

6 November 2017

1678-1687

1 reference

Impact of linker strain and flexibility in the design of a fragment-based inhibitor

6 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Image-based crystal detection: a machine-learning approach

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

PlasmoDB: a functional genomic database for malaria parasites

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Crystal structure of ultralente--a microcrystalline insulin suspension

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Structural genomics of pathogenic protozoa: an overview

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Recent developments in fragment-based drug discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Fragment-based approaches to enzyme inhibition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

A decade of fragment-based drug design: strategic advances and lessons learned

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Fragment-based lead discovery: leads by design

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Fragonomics: fragment-based drug discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

ZINC--a free database of commercially available compounds for virtual screening

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Design, expression, and purification of a Flaviviridae polymerase using a high-throughput approach to facilitate crystal structure determination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Fragment-based lead discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Automated analysis of vapor diffusion crystallization drops with an X-ray beam

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

GeneDB: a resource for prokaryotic and eukaryotic organisms

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

A deliberate approach to screening for initial crystallization conditions of biological macromolecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Towards the automated evaluation of crystallization trials

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

High-throughput crystallography for lead discovery in drug design.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Structure-based screening of low-affinity compounds

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Molecular complexity and its impact on the probability of finding leads for drug discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Discovering novel ligands for macromolecules using X-ray crystallographic screening

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Discovering high-affinity ligands for proteins: SAR by NMR

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Enzyme crystal structure in a neat organic solvent

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

In search of new lead compounds for trypanosomiasis drug design: a protein structure-based linked-fragment approach.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

LUDI: rule-based automatic design of new substituents for enzyme inhibitor leads

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Automated classification of protein crystallization images using support vector machines with scale-invariant texture and Gabor features.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Fragment-based lead discovery using X-ray crystallography.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Fragment-Based Drug Discovery

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Structures of purine 2'-deoxyribosyltransferase, substrate complexes, and the ribosylated enzyme intermediate at 2.0 A resolution

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

Functionality maps of binding sites: a multiple copy simultaneous search method

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897734

A new school for screening

25 November 2018

1 reference

12 December 2020

Purine salvage enzymes of parasites as targets for structure-based inhibitor design

1 reference

12 December 2020

Virtual exploration of the small-molecule chemical universe below 160 Daltons

1 reference

12 December 2020

Using Fragment Cocktail Crystallography To Assist Inhibitor Design ofTrypanosoma bruceiNucleoside 2-Deoxyribosyltransferase†

1 reference

12 December 2020

Fragment screening: an introduction

1 reference

12 December 2020

10.2174/156802609790102383

Identifiers

DOI

1 reference

6 November 2017

1 reference

6 November 2017

PubMed publication ID

19929835

1 reference