(Q27676179)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: unique role of halogen bonding revealed (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

0 references

1 reference

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

Joergen Philip Kiaer Ahring

18 January 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Christian Krintel

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Kasper Skytte Harpsøe

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Jette S Kastrup

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Line Aagot Hede Rohde

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Marianne Lerbech Jensen

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Elsebet Østergaard Nielsen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Dan Peters

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Charlotte Helgstrand

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Thomas Balle

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

English

0 references

publication date

13 December 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

18 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

287

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

4248-4259

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

18 January 2020

PyMOL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&rettype=xml&id=PMC3281707

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20 March 2017

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Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

20 March 2017

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Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis

20 March 2017

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Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore

20 March 2017

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Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

20 March 2017

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AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

20 March 2017

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

20 March 2017

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Structural changes in a cryo-cooled protein crystal owing to radiation damage

20 March 2017

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Specific chemical and structural damage to proteins produced by synchrotron radiation

20 March 2017

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A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy

20 March 2017

1 reference

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid

20 March 2017

1 reference

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Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

20 March 2017

1 reference

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Refined structure of the nicotinic acetylcholine receptor at 4A resolution

20 March 2017

1 reference

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Epibatidine structure-activity relationships

20 March 2017

1 reference

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

20 March 2017

1 reference

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Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

20 March 2017

1 reference

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New insights into the GABA(A) receptor structure and orthosteric ligand binding: receptor modeling guided by experimental data.

7 April 2017

1 reference

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The effects of nicotine, varenicline, and cytisine on schedule-controlled responding in mice: differences in α4β2 nicotinic receptor activation.

29 September 2017

1 reference

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Localization by site-directed mutagenesis of a galantamine binding site on α7 nicotinic acetylcholine receptor extracellular domain

29 September 2017

1 reference

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Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.

29 September 2017

1 reference

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Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors

29 September 2017

1 reference

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Varenicline in smoking cessation

29 September 2017

1 reference

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A medicinal chemist's guide to molecular interactions

29 September 2017

1 reference

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Gating of nicotinic ACh receptors: latest insights into ligand binding and function

29 September 2017

1 reference

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Insight in nAChR subtype selectivity from AChBP crystal structures.

29 September 2017

1 reference

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Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity

29 September 2017

1 reference

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Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site

29 September 2017

1 reference

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Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands.

29 September 2017

1 reference

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GABA(A) receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5IA, an alpha5 selective cognition enhancer

29 September 2017

1 reference

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Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.

29 September 2017

1 reference

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Structural determinates for apolipoprotein E-derived peptide interaction with the alpha7 nicotinic acetylcholine receptor

29 September 2017

1 reference

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Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors

29 September 2017

1 reference

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Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.

29 September 2017

1 reference

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Nicotine replacement therapy for long-term smoking cessation: a meta-analysis

29 September 2017

1 reference

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Brain nicotinic acetylcholine receptors: native subtypes and their relevance.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281707

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

29 September 2017

1 reference

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Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281707

Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel.

29 September 2017

1 reference

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Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors

29 September 2017

1 reference

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Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein

29 September 2017

1 reference

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Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors

29 September 2017

1 reference

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Human alpha4beta2 acetylcholine receptors formed from linked subunits.

29 September 2017

1 reference

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Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281707

Effects of the nicotinic acetylcholine receptor agonist SIB-1508Y on object retrieval performance in MPTP-treated monkeys: comparison with levodopa treatment

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281707

Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats.

2 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Inhibition of neuronal nicotinic acetylcholine receptor channels expressed in Xenopus oocytes by beta-amyloid1-42 peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Homology modeling and dynamics of the extracellular domain of rat and human neuronal nicotinic acetylcholine receptor subtypes alpha4beta2 and alpha7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

A glia-derived acetylcholine-binding protein that modulates synaptic transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

New ligands with affinity for the alpha4beta2 subtype of nicotinic acetylcholine receptors. Synthesis, receptor binding, and 3D-QSAR modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Docking to flexible nicotinic acetylcholine receptors: a validation study using the acetylcholine binding protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

alpha4beta2 nACh receptor pharmacophore models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Halogen bonding--a novel interaction for rational drug design?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Structural model for the binding sites of allosterically potentiating ligands on nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.292243

Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22170047

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Novel potent ligands for the central nicotinic acetylcholine receptor: synthesis, receptor binding, and 3D-QSAR analysis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22170047

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The 'fingerprint' that X-rays can leave on structures

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22170047

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.292243

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170047%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference