(Q27676754)

2

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Anna V Gromova

3

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Scott F Singleton

4

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Edward J Collins

5

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Andrew L Lee

Dynamics connect substrate recognition to catalysis in protein kinase A

6

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publication date

15 January 2012

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published in

Nature Chemical Biology

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volume

8

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issue

3

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page(s)

246-52

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cites work

1 reference

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20 March 2017

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Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

20 March 2017

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The GTPase superfamily: conserved structure and molecular mechanism

20 March 2017

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The dynamic energy landscape of dihydrofolate reductase catalysis

20 March 2017

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Intrinsic dynamics of an enzyme underlies catalysis

7 April 2017

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Drug-target residence time: critical information for lead optimization.

7 April 2017

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Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands

29 September 2017

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Residence time of receptor-ligand complexes and its effect on biological function

29 September 2017

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Conformational entropy in molecular recognition by proteins

29 September 2017

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High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate

29 September 2017

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Enzyme dynamics during catalysis

29 September 2017

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Studying excited states of proteins by NMR spectroscopy.

29 September 2017

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29 September 2017

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Kinetic pathways and barriers for ligand binding to myoglobin

29 September 2017

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Hydrogen Exchange in Proteins

29 September 2017

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Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

29 September 2017

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Dihydrofolate Reductase: X-ray Structure of the Binary Complex with Methotrexate

29 September 2017

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Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex

29 September 2017

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Multi-timescale dynamics study of FKBP12 along the rapamycin-mTOR binding coordinate.

2 June 2018

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Toward flexibility-activity relationships by NMR spectroscopy: dynamics of Pin1 ligands

2 June 2018

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Structure and dynamics of pin1 during catalysis by NMR.

2 June 2018

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Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes

2 June 2018

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Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli.

2 June 2018

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Dynamic dysfunction in dihydrofolate reductase results from antifolate drug binding: modulation of dynamics within a structural state

2 June 2018

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Reconstructing NMR spectra of "invisible" excited protein states using HSQC and HMQC experiments

21 January 2018

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Measuring Protein Concentrations by NMR Spectroscopy

21 January 2018

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A 2.13 Å Structure ofE. coliDihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region

21 January 2018

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Probing Chemical Shifts of Invisible States of Proteins with Relaxation Dispersion NMR Spectroscopy: How Well Can We Do?

21 January 2018

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Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function

21 January 2018

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12 December 2020

Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states

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12 December 2020

Deuterium exchange of poly-DL-alanine in aqueous solution

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12 December 2020

Dihydrofolate reductase hysteresis and its effect of inhibitor binding analyses

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12 December 2020