(Q27677462)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Botulinum neurotoxin is shielded by NTNHA in an interlocked complex (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Andreas Rummel

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Rongsheng Jin

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Shenyan Gu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Sophie Rumpel

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Jie Zhou

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Jasmin Strotmeier

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Hans Bigalke

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Charles B Shoemaker

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

language of work or name

English

0 references

publication date

1 February 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

number of pages

5

1 reference

inferred from page(s)

published in

Science

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

335

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

issue

6071

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

977-981

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic α-Exosite Binding Region

24 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

MolProbity: all-atom structure validation for macromolecular crystallography

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Structural basis of cell surface receptor recognition by botulinum neurotoxin B

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Role of metals in the biological activity of Clostridium botulinum neurotoxins

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Electrostatics of nanosystems: application to microtubules and the ribosome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Crystal structure of botulinum neurotoxin type A and implications for toxicity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Phasercrystallographic software

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Coot: model-building tools for molecular graphics

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

A graphical user interface to the CCP4 program suite

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

ESPript: analysis of multiple sequence alignments in PostScript

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Botulinum Toxin as a Biological Weapon: Medical and Public Health Management

20 March 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1214270

Systematic analysis of domain motions in proteins from conformational change: new results on citrate synthase and T4 lysozyme

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Very fast empirical prediction and rationalization of protein pKa values

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Botulinum neurotoxin: a marvel of protein design

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Expression of the Clostridium botulinum A2 neurotoxin gene cluster proteins and characterization of the A2 complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Protein ionizable groups: pK values and their contribution to protein stability and solubility

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

PROMALS: towards accurate multiple sequence alignments of distantly related proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Phylogeny and taxonomy of the food-borne pathogen Clostridium botulinum and its neurotoxins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Structure and function of tetanus and botulinum neurotoxins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Oral toxicities of Clostridium botulinum toxins in response to molecular size

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Electron density projection map of the botulinum neurotoxin 900-kilodalton complex by electron crystallography.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

The complete nucleotide sequence of the gene encoding the nontoxic component of Clostridium botulinum type E progenitor toxin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545708

HA-33 facilitates transport of the serotype D botulinum toxin across a rat intestinal epithelial cell monolayer

2 June 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1214270

Studies on the dissociation of botulinum neurotoxin type A complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1214270

Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1214270

A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1214270

In vitro reconstitution of the Clostridium botulinum type D progenitor toxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1214270

Substrate recognition strategy for botulinum neurotoxin serotype A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1214270

Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1214270

Molecular characterization of two forms of nontoxic-nonhemagglutinin components of Clostridium botulinum type A progenitor toxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1214270

Probing the mechanistic role of glutamate residue in the zinc-binding motif of type A botulinum neurotoxin light chain

21 January 2018

1 reference

12 December 2020

Spontaneous nicking in the nontoxic-nonhemagglutinin component of the Clostridium botulinum toxin complex

1 reference

12 December 2020

Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tango

1 reference

12 December 2020

Effects of purification on the bioavailability of botulinum neurotoxin type A

1 reference

12 December 2020

A role for the interchain disulfide or its participating thiols in the internalization of botulinum neurotoxin A revealed by a toxin derivative that binds to ecto-acceptors and inhibits transmitter release intracellularly

1 reference

12 December 2020

Light Chain of Botulinum Neurotoxin Serotype A: Structural Resolution of a Catalytic Intermediate†,‡

1 reference

12 December 2020

Conserved structure of genes encoding components of botulinum neurotoxin complex M and the sequence of the gene coding for the nontoxic component in nonproteolytic Clostridium botulinum type F

1 reference

12 December 2020

Identifiers

DOI

10.1126/SCIENCE.1214270

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22363010%20AND%20SRC:MED&resulttype=core&format=json