(Q27677537)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22376008%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Synthesis, X-ray analysis, and biological evaluation of a new class of stereopure lactam-based HIV-1 protease inhibitors (English)

1 reference

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24 January 2020

0 references

1

1 reference

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24 January 2020

12

Mats Larhed

1 reference

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24 January 2020

author name string

Per Ohrngren

2

1 reference

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24 January 2020

Advait A Joshi

3

1 reference

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24 January 2020

Alejandro Trejos

4

1 reference

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24 January 2020

Magnus Persson

5

1 reference

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24 January 2020

Riina K Arvela

6

1 reference

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24 January 2020

Hans Wallberg

7

1 reference

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24 January 2020

Lotta Vrang

8

1 reference

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24 January 2020

Asa Rosenquist

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22376008%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Bertil B Samuelsson

10

1 reference

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24 January 2020

Johan Unge

11

1 reference

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24 January 2020

language of work or name

English

0 references

publication date

13 March 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22376008%20AND%20SRC:MED&resulttype=core&format=json

Journal of Medicinal Chemistry

24 January 2020

published in

1 reference

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24 January 2020

volume

55

1 reference

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24 January 2020

issue

6

1 reference

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24 January 2020

page(s)

2724-2736

1 reference

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HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells

24 January 2020

cites work

1 reference

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Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic

20 March 2017

1 reference

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Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution

20 March 2017

1 reference

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Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

20 March 2017

1 reference

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Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

20 March 2017

1 reference

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On the size of the active site in proteases. I. Papain

20 March 2017

1 reference

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HIV-1 protease: mechanism and drug discovery

20 March 2017

1 reference

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Asymmetric carbon-carbon bond formations in conjugate additions of lithiated N-Boc allylic and benzylic amines to nitroalkenes: enantioselective synthesis of substituted piperidines, pyrrolidines, and pyrimidinones

20 March 2017

1 reference

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BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents

20 March 2017

1 reference

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Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)

20 March 2017

1 reference

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Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

20 March 2017

1 reference

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Rational design of peptide-based HIV proteinase inhibitors

20 March 2017

1 reference

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Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

20 March 2017

1 reference

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Current and Novel Inhibitors of HIV Protease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

HIV-1 Protease: Structural Perspectives on Drug Resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Atazanavir metabolism according to CYP3A5 status: an in vitro-in vivo assessment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Recent advances in antiretroviral drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Current status and challenges of antiretroviral research and therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Understanding and managing the adverse effects of antiretroviral therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?

29 September 2017

1 reference

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Viral protease inhibitors

29 September 2017

1 reference

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Inhibitors of HIV-1 protease: current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors

29 September 2017

1 reference

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Protease inhibitor-based regimens for HIV therapy: safety and efficacy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Microwave-accelerated synthesis of P1'-extended HIV-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

The impact of microwave synthesis on drug discovery.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

29 September 2017

Update on HAART in HIV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

A new class of HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Peptidomimetic inhibitors of HIV protease

29 September 2017

1 reference

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Toxicity of antiretroviral therapy and implications for drug development

29 September 2017

1 reference

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Microwave-accelerated homogeneous catalysis in organic chemistry

29 September 2017

1 reference

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Atazanavir: a novel HIV-1 protease inhibitor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group.

29 September 2017

1 reference

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A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team

29 September 2017

1 reference

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Structure-based inhibitors of HIV-1 protease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors: candidates for clinical development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

The accuracy of reverse transcriptase from HIV-1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Room-Temperature Ionic Liquids: Solvents for Synthesis and Catalysis. 2

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Asymmetric synthesis of pyrrolidinoindolines. Application for the practical total synthesis of (-)-phenserine

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Reaction of malondialdehyde-DNA adducts with hydrazines-development of a facile assay for quantification of malondialdehyde equivalents in DNA.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Synthesis of Acyclic Precursors to (3S,4S)-4-Hydroxy-2,3,4,5-tetrahydropyridazine-3-carboxylic Acid and Incorporation into a Luzopeptin/Quinoxapeptin Dipeptide

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310203

Enantioselective synthesis of 3,3-disubstituted piperidine derivatives by enolate dialkylation of phenylglycinol-derived oxazolopiperidone lactams

27 November 2018

1 reference

12 December 2020

Comparison of the specificity of homo- and heterodimeric linked HIV-1 and HIV-2 proteinase dimers

1 reference

12 December 2020

Fast, acid-free, and selective lactamization of lactones in ionic liquids

1 reference

12 December 2020

Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog

1 reference

12 December 2020

N-substituted 2-pyrrolidones

1 reference

12 December 2020

1 reference

12 December 2020

Conformationally constrained renin inhibitory peptides: gamma-lactam-bridged dipeptide isostere as conformational restriction

1 reference

12 December 2020

Expeditious syntheses of sugar-modified nucleosides and collections thereof exploiting furan-, pyrrole-, and thiophene-based siloxy dienes

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM201620T

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22376008%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22376008%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

22376008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22376008%20AND%20SRC:MED&resulttype=core&format=json