(Q27678097)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity (English)

1 reference

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26 January 2020

5

1 reference

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26 January 2020

7

Benjamin P Fauber

1 reference

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26 January 2020

10

David Stokoe

1 reference

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26 January 2020

author name string

Till Maurer

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Lindsay S Garrenton

2

1 reference

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26 January 2020

Angela Oh

3

1 reference

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26 January 2020

Keith Pitts

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Nicholas J Skelton

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Borlan Pan

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Shiva Malek

9

1 reference

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26 January 2020

Mary J C Ludlam

11

1 reference

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26 January 2020

Krista K Bowman

12

1 reference

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26 January 2020

Jiansheng Wu

13

1 reference

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26 January 2020

Anthony M Giannetti

14

1 reference

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26 January 2020

Melissa A Starovasnik

15

1 reference

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26 January 2020

Ira Mellman

16

1 reference

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26 January 2020

Peter K Jackson

17

1 reference

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26 January 2020

Joachim Rudolph

18

1 reference

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26 January 2020

Weiru Wang

19

1 reference

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26 January 2020

Guowei Fang

20

1 reference

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26 January 2020

language of work or name

English

0 references

publication date

19 March 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

26 January 2020

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

volume

109

1 reference

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26 January 2020

page(s)

5299-5304

1 reference

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26 January 2020

issue

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

26 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

The structural basis of the activation of Ras by Sos

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

The guanine nucleotide-binding switch in three dimensions

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

A Ras-induced conformational switch in the Ras activator Son of sevenless

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Hyperactive Ras in developmental disorders and cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

An orthosteric inhibitor of the Ras-Sos interaction

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

From fragment to clinical candidate--a historical perspective.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Detection and structural characterization of ras oncoprotein-inhibitors complexes by electrospray mass spectrometry

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325706

Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements

29 September 2017

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22431598

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22431598

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1116510109

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

ADS bibcode

2012PNAS..109.5299M

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22431598%20AND%20SRC:MED&resulttype=core&format=json