(Q27679277)

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Structural Characterization and Computer-Aided Optimization of a Small-Molecule Inhibitor of the Arp2/3 Complex, a Key Regulator of the Actin Cytoskeleton

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scholarly article

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Europe PubMed Central

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2 February 2020

Structural characterization and computer-aided optimization of a small-molecule inhibitor of the Arp2/3 complex, a key regulator of the actin cytoskeleton (English)

1 reference

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2 February 2020

organic chemistry

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actin cytoskeleton

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2

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2 February 2020

6

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2 February 2020

author name string

Andrew W Baggett

1

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2 February 2020

Min Suk Han

3

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2 February 2020

George Patargias

4

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2 February 2020

Adam C Glass

5

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2 February 2020

Brad J Nolen

7

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2 February 2020

publication date

23 May 2012

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2 February 2020

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2 February 2020

7

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2 February 2020

7

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2 February 2020

1286-1294

1 reference

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2 February 2020

Characterization of two classes of small molecule inhibitors of Arp2/3 complex

1 reference

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Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin

1 reference

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1 reference

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1 reference

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

1 reference

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20 March 2017

Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes

1 reference

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20 March 2017

Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes

1 reference

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20 March 2017

Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization

1 reference

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A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531959

20 March 2017

Actin, a central player in cell shape and movement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531959

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Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

1 reference

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7 April 2017

The ARP2/3 complex: an actin nucleator comes of age

1 reference

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Interfacial inhibitors: targeting macromolecular complexes

1 reference

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29 September 2017

Cortical actin binding protein cortactin mediates ENaC activity via Arp2/3 complex

1 reference

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29 September 2017

Nucleating actin for invasion

1 reference

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29 September 2017

New mechanisms and functions of actin nucleation

1 reference

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29 September 2017

Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)

1 reference

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Actin-based motility drives baculovirus transit to the nucleus and cell surface

1 reference

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29 September 2017

Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly

1 reference

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29 September 2017

Perspective on Free-Energy Perturbation Calculations for Chemical Equilibria

1 reference

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Efficient drug lead discovery and optimization

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Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening

1 reference

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Optimization of azoles as anti-human immunodeficiency virus agents guided by free-energy calculations

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29 September 2017

The structural basis of actin filament branching by the Arp2/3 complex

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531959

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Regulation of cancer cell motility through actin reorganization

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531959

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Actin-based motility of intracellular pathogens

1 reference

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Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP.

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531959

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1 reference

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1 reference

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Kinetic evidence for a monomer activation step in actin polymerization.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200104

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Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200104

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1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200104

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1 reference

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1 reference

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12 December 2020

based on heuristic

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Halogen-water-hydrogen bridges in biomolecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623398

12 December 2020

based on heuristic

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Identification of a factor in conventional muscle actin preparations which inhibits actin filament self-association

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arp2/3 overexpression contributed to pathogenesis, growth and invasion of gastric carcinoma

1 reference

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12 December 2020

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1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200104

7 January 2021

based on heuristic

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10.1002/CMDC.201200104

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Europe PubMed Central

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2 February 2020

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Europe PubMed Central

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2 February 2020

1 reference

Europe PubMed Central

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2 February 2020

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