(Q37968897)

26 August 2017

Interfacial inhibitors: targeting macromolecular complexes (English)

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26 August 2017

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1

Yves Pommier

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26 August 2017

Christophe Marchand

2

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26 August 2017

16 December 2011

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Nature Reviews Drug Discovery

26 August 2017

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26 August 2017

11

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26 August 2017

1

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26 August 2017

25-36

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https://scigraph.springernature.com/pub.10.1038/nrd3404

26 August 2017

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cites work

Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells

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Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

21 January 2018

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Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

21 January 2018

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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

21 January 2018

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

21 January 2018

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Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

21 January 2018

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

21 January 2018

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Interfacial inhibitors of protein-nucleic acid interactions

21 January 2018

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Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

21 January 2018

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Type IIA topoisomerase inhibition by a new class of antibacterial agents

21 January 2018

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Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.

21 January 2018

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Structure-based modeling of the functional HIV-1 intasome and its inhibition

21 January 2018

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Retroviral intasome assembly and inhibition of DNA strand transfer

21 January 2018

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Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide

21 January 2018

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Mechanisms of camptothecin resistance by human topoisomerase I mutations

21 January 2018

1 reference

Topoisomerase I inhibitors: selectivity and cellular resistance.

21 January 2018

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DNA topoisomerase-targeting antitumor drugs can be studied in yeast

21 January 2018

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Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants

21 January 2018

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Topoisomerase I inhibitors: camptothecins and beyond

21 January 2018

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Repair of topoisomerase I-mediated DNA damage

21 January 2018

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Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.

21 January 2018

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Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

21 January 2018

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Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs

21 January 2018

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The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action

21 January 2018

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Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain

21 January 2018

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Exposing plasmids as the Achilles' heel of drug-resistant bacteria

21 January 2018

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Molecular basis of gyrase poisoning by the addiction toxin CcdB.

21 January 2018

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Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events

21 January 2018

1 reference

Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187

21 January 2018

1 reference

Microtubule-binding agents: a dynamic field of cancer therapeutics

21 January 2018

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Microtubules as a target for anticancer drugs

21 January 2018

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Structural basis for the regulation of tubulin by vinblastine

21 January 2018

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Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

21 January 2018

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HIV-1 IN inhibitors: 2010 update and perspectives

21 January 2018

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Resistance to integrase inhibitors

21 January 2018

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Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143.

21 January 2018

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Integrase inhibitors to treat HIV/AIDS.

21 January 2018

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Structural biology of retroviral DNA integration

21 January 2018

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Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors

21 January 2018

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

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Nicotinic receptors, allosteric proteins and medicine.

21 January 2018

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Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

21 January 2018

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50th anniversary of the word "allosteric".

21 January 2018

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Allosteric proteins and cellular control systems

21 January 2018

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DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata

21 January 2018

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Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*

21 January 2018

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The mechanism of retroviral integration from X-ray structures of its key intermediates

21 January 2018

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Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation

21 January 2018

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Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution

21 January 2018

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Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

21 January 2018

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X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

21 January 2018

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A closer look at the high affinity benzodiazepine binding site on GABAA receptors

21 January 2018

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Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

21 January 2018

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Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism

21 January 2018

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Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

21 January 2018

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Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

21 January 2018

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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

21 January 2018

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Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

21 January 2018

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Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.

21 January 2018

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The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

21 January 2018

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Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

21 January 2018

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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

21 January 2018

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Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

21 January 2018

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Structural view of a fungal toxin acting on a 14-3-3 regulatory complex

21 January 2018

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Structural studies of the translational apparatus

21 January 2018

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Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site

21 January 2018

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Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis

21 January 2018

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Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

21 January 2018

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Direct inhibition of the NOTCH transcription factor complex

21 January 2018

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A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase

21 January 2018

1 reference

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density

21 January 2018

1 reference

Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain

21 January 2018

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Antitumour drugs impede DNA uncoiling by topoisomerase I

21 January 2018

1 reference

Correction: Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases.

21 January 2018

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Catalytic inhibitors of DNA topoisomerase II

31 March 2020

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Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

31 March 2020

1 reference

12 December 2020

Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

1 reference

12 December 2020

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

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12 December 2020

Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity

1 reference

12 December 2020

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

1 reference

12 December 2020

Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin

1 reference

12 December 2020

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

1 reference

12 December 2020

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12 December 2020

Structural basis of gate-DNA breakage and resealing by type II topoisomerases

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12 December 2020

Identifiers

DOI

10.1038/NRD3404

1 reference

26 August 2017

0 references

1 reference

PubMed ID

22173432