(Q27670929)

2

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Lynn Farh

3

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Li-Ying Lin

4

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Te-Sheng Lin

5

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Yu-Jen Yu

6

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Tien-Jui Yen

7

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Chia-Wang Chiang

8

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Nei-Li Chan

Cellular roles of dna topoisomerases: a molecular perspective

9

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language of work or name

English

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publication date

22 July 2011

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published in

Science

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volume

333

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issue

6041

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page(s)

459-62

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cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1204117

Targeting DNA topoisomerase II in cancer chemotherapy

21 April 2017

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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

21 April 2017

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Structural basis of gate-DNA breakage and resealing by type II topoisomerases

21 April 2017

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Type IIA topoisomerase inhibition by a new class of antibacterial agents

21 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1204117

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

21 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1204117

Structural basis for gate-DNA recognition and bending by type IIA topoisomerases

21 April 2017

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Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

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Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

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Structure and mechanism of DNA topoisomerase II

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https://api.crossref.org/works/10.1126/SCIENCE.1204117

mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity

21 April 2017

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Topoisomerase IIalpha gene (TOP2A) amplification and deletion in cancer--more common than anticipated

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Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspective

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DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

21 January 2018

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The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

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DNA topoisomerase II, genotoxicity, and cancer

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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

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Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.

21 January 2018

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Recent developments in the chemistry of deoxyribonucleic acid (DNA) intercalators: principles, design, synthesis, applications and trends

21 January 2018

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A two-drug model for etoposide action against human topoisomerase IIalpha

21 January 2018

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Etoposide: discovery and medicinal chemistry

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Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

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Structure-activity relationships of VP-16 analogues

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DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action

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Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage

21 January 2018

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Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.

21 January 2018

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Role of topoisomerase IIbeta in the expression of developmentally regulated genes.

21 January 2018

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A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

21 January 2018

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