(Q34397376)

1 August 2017

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title

Integrase inhibitors to treat HIV/AIDS. (English)

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1 August 2017

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1

Yves Pommier

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1 August 2017

Allison A Johnson

2

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PubMed ID

15729361

1 August 2017

Christophe Marchand

series ordinal

3

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1 August 2017

1 March 2005

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Nature Reviews Drug Discovery

1 August 2017

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1 August 2017

4

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1 August 2017

236-248

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1 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nrd1660

1 August 2017

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Repair of gaps in retroviral DNA integration intermediates

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Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway

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Transcription start regions in the human genome are favored targets for MLV integration

31 March 2020

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Structure and function of HIV-1 integrase

31 March 2020

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Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

31 March 2020

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Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

31 March 2020

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Recombining the structures of HIV integrase, RuvC and RNase H.

31 March 2020

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Crystal structure of Argonaute and its implications for RISC slicer activity

31 March 2020

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Comparative architecture of transposase and integrase complexes

31 March 2020

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Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity

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31 March 2020

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31 March 2020

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Effect of HIV integrase inhibitors on the RAG1/2 recombinase

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31 March 2020

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Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents

31 March 2020

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A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

31 March 2020

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Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations

31 March 2020

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Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells

31 March 2020

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Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro

31 March 2020

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Nuclear import of HIV-1 integrase is inhibited in vitro by styrylquinoline derivatives

31 March 2020

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Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture

31 March 2020

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Discovery of HIV-1 integrase inhibitors by pharmacophore searching.

31 March 2020

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31 March 2020

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Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds

31 March 2020

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Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures

31 March 2020

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Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.

31 March 2020

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Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.

31 March 2020

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Thiazolothiazepine inhibitors of HIV-1 integrase

31 March 2020

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Thalassiolins A-C: new marine-derived inhibitors of HIV cDNA integrase

31 March 2020

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31 March 2020

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Inhibition of human immunodeficiency virus type-1 integrase by curcumin

31 March 2020

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Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin

31 March 2020

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Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design

31 March 2020

1 reference

Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor

31 March 2020

1 reference

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

31 March 2020

1 reference

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells

31 March 2020

1 reference

Structural determinants for HIV-1 integrase inhibition by beta-diketo acids

31 March 2020

1 reference

Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.

31 March 2020

1 reference

Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors

31 March 2020

1 reference

Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes

31 March 2020

1 reference

Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites

31 March 2020

1 reference

Expanding the repertoire of heterocycle ring pairs for programmable minor groove DNA recognition

31 March 2020

1 reference

Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA

31 March 2020

1 reference

Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules

31 March 2020

1 reference

Integration complexes derived from HIV vectors for rapid assays in vitro

31 March 2020

1 reference

HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Differential divalent cation requirements uncouple the assembly and catalytic reactions of human immunodeficiency virus type 1 integrase.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1660

1 reference

1 August 2017

1 reference

PubMed ID

15729361